Caffeine dependence in rats: Effects of exposure duration and concentration

Abstract Groups of rats were chronically exposed to a 1.0-g/L caffeine solution for 5, 10, 15 or 20 days. Upon removal of caffeine, rats were given brief exposure to a novel flavour CS (withdrawal CS) followed by 12 days of plain water and then brief exposure to a second flavour CS (neutral CS). Onl...

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Bibliographic Details
Published in:Physiology & behavior 2008-09, Vol.95 (1), p.252-257
Main Authors: Dingle, Rachel N, Dreumont-Boudreau, Sarah E, LoLordo, Vincent M
Format: Article
Language:English
Subjects:
Animals
Associative learning
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Caffeine
Caffeine - adverse effects
Central Nervous System Stimulants - adverse effects
Conditioned avoidance
Conditioning, Classical - drug effects
Conditioning, Classical - physiology
Dependence
Dose
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopharmacology
Rats
Rats, Sprague-Dawley
Substance-Related Disorders - etiology
Time Factors
Withdrawal
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Summary:Abstract Groups of rats were chronically exposed to a 1.0-g/L caffeine solution for 5, 10, 15 or 20 days. Upon removal of caffeine, rats were given brief exposure to a novel flavour CS (withdrawal CS) followed by 12 days of plain water and then brief exposure to a second flavour CS (neutral CS). Only rats exposed to 20 days of caffeine strongly preferred the neutral CS to the withdrawal CS in a 2-bottle test. In Experiment 2, groups of rats were chronically exposed to caffeine at one of four concentrations (1.0, 0.5, 0.25, or 0.125 g/L) for 21 days, after which withdrawal and neutral CSs were established. Only rats that drank the highest caffeine concentration, 1.0 g/L, preferred the neutral CS to the withdrawal CS. This suggests that long exposure to a strong caffeine solution is required in order to induce dependence in rats such that a CS associated with the withdrawal of caffeine becomes avoided.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2008.06.007