Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama)

Abstract Nootropic, antioxidant, and neuroprotective properties have been shown in a standardized ethanol extract of Ptychopetalum olacoides (POEE), a medicinal plant traditionally used by the Amazonian elderly population. It has been revealed that POEE mechanisms of action include anticholinesteras...

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Bibliographic Details
Published in:Physiology & behavior 2008-09, Vol.95 (1), p.88-92
Main Authors: da Silva, Adriana Lourenço, Ferreira, Juliana G, da Silva Martins, Bárbara, Oliveira, Sabrina, Mai, Nathalia, Nunes, Domingos S, Elisabetsky, Elaine
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Interactions
Fundamental and applied biological sciences. Psychology
Male
Marapuama
Memory
Memory - classification
Memory - drug effects
Mice
Neurodegenerative disorders
Olacaceae - chemistry
Pindolol - pharmacology
Plant Extracts - pharmacology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Ptychopetalum olacoides
Reaction Time - drug effects
Receptors, Serotonin - metabolism
Serotonin Antagonists - pharmacology
Serotoninergic
Spiperone - pharmacology
Statistics, Nonparametric
Step-down
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Summary:Abstract Nootropic, antioxidant, and neuroprotective properties have been shown in a standardized ethanol extract of Ptychopetalum olacoides (POEE), a medicinal plant traditionally used by the Amazonian elderly population. It has been revealed that POEE mechanisms of action include anticholinesterase effects, and involve β-adrenergic and dopamine D1 receptors. The purpose of this study was to verify the role of serotonin receptors in the promnesic effects of this standardized extract. The step-down task in mice and selective serotonin antagonists were used. The study reveals that POEE promnesic effects on short-term (acquisition, consolidation and retrieval) and long-term (retrieval) declarative aversive memories are increased by 5HT2A (but not 5HT1A ) serotonin antagonists (spiperone and pindolol, respectively). The observed synergism between POEE and spiperone can be interpreted as the combined effects of two subeffective doses of two 5HT antagonists, or the known synergism between an acetylcholinesterase inhibitor (POEE) and a 5HT antagonist. In conclusion it is suggested that 5HT2A serotonin receptors are relevant for the promnesic effects of this extract, adding to its multiple mechanisms of action.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2008.04.022