Prevention of radiation-induced damages by aqueous extract of Ganoderma lucidum occurring in southern parts of India

Our previous studies have demonstrated that aqueous extract of Ganoderma lucidum occurring in South India possessed significant antioxidant activity. The present study was aimed at evaluating the radioprotective properties of the aqueous extract of this mushroom. Single-cell gel electrophoresis (com...

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Bibliographic Details
Published in:Current science (Bangalore) 2006-08, Vol.91 (3), p.341-344
Main Authors: Pillai, Thulasi G., Salvi, Veena P., Maurya, Dharmendra Kumar, Nair, Cherupally Krishnan Krishnan, Janardhanan, K. K.
Format: Article
Language:English
Subjects:
Comets
DNA
DNA damage
Flood damage
Ganoderma lucidum
Lipids
Mushrooms
Plasmids
Radiation damage
Radiation protection
Reishi
RESEARCH COMMUNICATIONS
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Summary:Our previous studies have demonstrated that aqueous extract of Ganoderma lucidum occurring in South India possessed significant antioxidant activity. The present study was aimed at evaluating the radioprotective properties of the aqueous extract of this mushroom. Single-cell gel electrophoresis (comet assay), protection of radiation-induced plasmid pBR322 DNA strand breaks and inhibitions of lipid peroxidation (TBARS assay) were employed to determine the level of protection offered by the extract. The results indicate that aqueous extract of G. lucidum possessed significant radioprotective activity. The findings suggest the potential use of this mushroom extract for the prevention of radiation-induced cellular damages.
ISSN:0011-3891