Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8 super(+) T Cells with Potent Recall Function

The role of human bone marrow (BM) CD8 super(+) T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 super(+) T cell population (T sub(EM)) in the BM of patients undergoing total joint rep...

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Bibliographic Details
Published in:Journal of Immunology 2006-11, Vol.177 (10), p.6730-6737
Main Authors: Zhang, Xiaoyu, Dong, Haidong, Lin, Wei, Voss, Stephen, Hinkley, Lucinda, Westergren, Melissa, Tian, Guoliang, Berry, Daniel, Lewellen, David, Vile, Richard G, Chen, Lieping, Farber, Donna L, Strome, Scott E
Format: Article
Language:English
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Summary:The role of human bone marrow (BM) CD8 super(+) T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 super(+) T cell population (T sub(EM)) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived T sub(EM) differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM T sub(EM) have low levels of resting perforin and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the T sub(EM) subset in PB, BM CD8 super(+) T sub(EM) cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-specific T sub(EM) with great therapeutic potential in vaccine development.
ISSN:0022-1767
1365-2567