Overcoming ocular drug delivery barriers through the use of physical forces

Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceutical strategies, such as novel formulations and physical force-based te...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2018-02, Vol.126, p.96-112
Main Authors: Huang, Di, Chen, Ying-Shan, Rupenthal, Ilva D.
Format: Article
Language:English
Subjects:
Electrical fields
Electroporation
Iontophoresis
Microneedles
Ocular drug delivery
Physiological barriers
Sonophoresis
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Summary:Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery. While ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceutical strategies, such as novel formulations and physical force-based techniques, have been investigated to weaken these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, which can enhance penetration efficiency by transiently disrupting the ocular barriers in a minimally or non-invasive manner. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2017.09.008