Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia

Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2017-12, Vol.78 (6), p.n/a
Main Authors: El‐Chennawi, Farha, Rageh, Ibrahim Mohamed, Mansour, Amira Ibrahim, Darwish, Mohammed Ibrahim, Elghzaly, Ashraf Antar, Sakr, Basma El Sayed, Elbaz, Khaled Mohsen
Format: Article
Language:English
Subjects:
flow cytometry
FOXP3
preeclampsia
regulatory T cells
umbilical cord blood
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Summary:Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12761