Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia

Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born...

Full description

Saved in:
Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2017-12, Vol.78 (6), p.n/a
Main Authors: El‐Chennawi, Farha, Rageh, Ibrahim Mohamed, Mansour, Amira Ibrahim, Darwish, Mohammed Ibrahim, Elghzaly, Ashraf Antar, Sakr, Basma El Sayed, Elbaz, Khaled Mohsen
Format: Article
Language:English
Subjects:
flow cytometry
FOXP3
preeclampsia
regulatory T cells
umbilical cord blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page n/a
container_issue 6
container_start_page
container_title American journal of reproductive immunology (1989)
container_volume 78
creator El‐Chennawi, Farha
Rageh, Ibrahim Mohamed
Mansour, Amira Ibrahim
Darwish, Mohammed Ibrahim
Elghzaly, Ashraf Antar
Sakr, Basma El Sayed
Elbaz, Khaled Mohsen
description Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.
doi_str_mv 10.1111/aji.12761
format article
fullrecord <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_miscellaneous_1940190673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1940190673</sourcerecordid><originalsourceid>FETCH-LOGICAL-p731-65a3581b2ca0fea13130501c46096b0283984f6df029495e1abe45dd7475943a3</originalsourceid><addsrcrecordid>eNpNkU1uwjAQhaOqlUppF72Bl5UgMI6dvyUKpaVCogsW3UVO4hAjJ07tIMRtuEd3nKxJQGpnM0_fPL1ZPMt6xjDB7UzZTkyw43v4xhpgD8CGIPRvWw3Us30Kwb31YMwOoOXEH1g_kSprpoVRFVI5agqOaq5TXjVsy02HojkdnU_R3HELsS3Op8X665OMxv-4VIc_zKrseroQtNF8a8ZIVH34vkyEFCmTKFU6Q4lUKuu-JCwR7b9E6danUKlaszboIJqij-yE2jeo1pynkpW1EezRusuZNPzpuofWZvG6id7t1fptGc1Wdu0TbHsuI26AEydlkHOGCSbgAk6pB6GXgBOQMKC5l-XghDR0OWYJp26W-dR3Q0oYGVovl9haq-89N01cCpNyKVnF1d7EOKSAQ_B80lqnF-tBSH6May1Kpo8xhrgrJ27Lifty4tnHshfkF5RlhJE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1940190673</pqid></control><display><type>article</type><title>Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia</title><source>Wiley</source><creator>El‐Chennawi, Farha ; Rageh, Ibrahim Mohamed ; Mansour, Amira Ibrahim ; Darwish, Mohammed Ibrahim ; Elghzaly, Ashraf Antar ; Sakr, Basma El Sayed ; Elbaz, Khaled Mohsen</creator><creatorcontrib>El‐Chennawi, Farha ; Rageh, Ibrahim Mohamed ; Mansour, Amira Ibrahim ; Darwish, Mohammed Ibrahim ; Elghzaly, Ashraf Antar ; Sakr, Basma El Sayed ; Elbaz, Khaled Mohsen</creatorcontrib><description>Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12761</identifier><language>eng</language><subject>flow cytometry ; FOXP3 ; preeclampsia ; regulatory T cells ; umbilical cord blood</subject><ispartof>American journal of reproductive immunology (1989), 2017-12, Vol.78 (6), p.n/a</ispartof><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-3612-1918</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>El‐Chennawi, Farha</creatorcontrib><creatorcontrib>Rageh, Ibrahim Mohamed</creatorcontrib><creatorcontrib>Mansour, Amira Ibrahim</creatorcontrib><creatorcontrib>Darwish, Mohammed Ibrahim</creatorcontrib><creatorcontrib>Elghzaly, Ashraf Antar</creatorcontrib><creatorcontrib>Sakr, Basma El Sayed</creatorcontrib><creatorcontrib>Elbaz, Khaled Mohsen</creatorcontrib><title>Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia</title><title>American journal of reproductive immunology (1989)</title><description>Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.</description><subject>flow cytometry</subject><subject>FOXP3</subject><subject>preeclampsia</subject><subject>regulatory T cells</subject><subject>umbilical cord blood</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpNkU1uwjAQhaOqlUppF72Bl5UgMI6dvyUKpaVCogsW3UVO4hAjJ07tIMRtuEd3nKxJQGpnM0_fPL1ZPMt6xjDB7UzZTkyw43v4xhpgD8CGIPRvWw3Us30Kwb31YMwOoOXEH1g_kSprpoVRFVI5agqOaq5TXjVsy02HojkdnU_R3HELsS3Op8X665OMxv-4VIc_zKrseroQtNF8a8ZIVH34vkyEFCmTKFU6Q4lUKuu-JCwR7b9E6danUKlaszboIJqij-yE2jeo1pynkpW1EezRusuZNPzpuofWZvG6id7t1fptGc1Wdu0TbHsuI26AEydlkHOGCSbgAk6pB6GXgBOQMKC5l-XghDR0OWYJp26W-dR3Q0oYGVovl9haq-89N01cCpNyKVnF1d7EOKSAQ_B80lqnF-tBSH6May1Kpo8xhrgrJ27Lifty4tnHshfkF5RlhJE</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>El‐Chennawi, Farha</creator><creator>Rageh, Ibrahim Mohamed</creator><creator>Mansour, Amira Ibrahim</creator><creator>Darwish, Mohammed Ibrahim</creator><creator>Elghzaly, Ashraf Antar</creator><creator>Sakr, Basma El Sayed</creator><creator>Elbaz, Khaled Mohsen</creator><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3612-1918</orcidid></search><sort><creationdate>201712</creationdate><title>Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia</title><author>El‐Chennawi, Farha ; Rageh, Ibrahim Mohamed ; Mansour, Amira Ibrahim ; Darwish, Mohammed Ibrahim ; Elghzaly, Ashraf Antar ; Sakr, Basma El Sayed ; Elbaz, Khaled Mohsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p731-65a3581b2ca0fea13130501c46096b0283984f6df029495e1abe45dd7475943a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>flow cytometry</topic><topic>FOXP3</topic><topic>preeclampsia</topic><topic>regulatory T cells</topic><topic>umbilical cord blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El‐Chennawi, Farha</creatorcontrib><creatorcontrib>Rageh, Ibrahim Mohamed</creatorcontrib><creatorcontrib>Mansour, Amira Ibrahim</creatorcontrib><creatorcontrib>Darwish, Mohammed Ibrahim</creatorcontrib><creatorcontrib>Elghzaly, Ashraf Antar</creatorcontrib><creatorcontrib>Sakr, Basma El Sayed</creatorcontrib><creatorcontrib>Elbaz, Khaled Mohsen</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El‐Chennawi, Farha</au><au>Rageh, Ibrahim Mohamed</au><au>Mansour, Amira Ibrahim</au><au>Darwish, Mohammed Ibrahim</au><au>Elghzaly, Ashraf Antar</au><au>Sakr, Basma El Sayed</au><au>Elbaz, Khaled Mohsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><date>2017-12</date><risdate>2017</risdate><volume>78</volume><issue>6</issue><epage>n/a</epage><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem Little is known about how preeclampsia affects regulatory T‐cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study The percentage of umbilical cord blood CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs were analyzed by flow cytometry. Results CD4+ CD25high FOXP3+ Treg (%) and CD4+ FOXP3+ Treg (%) were significantly lower, while CD4+ CD25low (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4+ CD25high FOXP3+) in the umbilical cord blood of babies born to preeclamptic mothers.</abstract><doi>10.1111/aji.12761</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3612-1918</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1046-7408
ispartof American journal of reproductive immunology (1989), 2017-12, Vol.78 (6), p.n/a
issn 1046-7408
1600-0897
language eng
recordid cdi_proquest_miscellaneous_1940190673
source Wiley
subjects flow cytometry
FOXP3
preeclampsia
regulatory T cells
umbilical cord blood
title Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T19%3A17%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20the%20percentages%20of%20CD4+%C2%A0CD25high%C2%A0FOXP3+,%20CD4+%C2%A0CD25low%C2%A0FOXP3+,%20and%20CD4+%C2%A0FOXP3+%20Tregs,%20in%20the%20umbilical%20cord%20blood%20of%20babies%20born%20to%20mothers%20with%20and%20without%20preeclampsia&rft.jtitle=American%20journal%20of%20reproductive%20immunology%20(1989)&rft.au=El%E2%80%90Chennawi,%20Farha&rft.date=2017-12&rft.volume=78&rft.issue=6&rft.epage=n/a&rft.issn=1046-7408&rft.eissn=1600-0897&rft_id=info:doi/10.1111/aji.12761&rft_dat=%3Cproquest_wiley%3E1940190673%3C/proquest_wiley%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p731-65a3581b2ca0fea13130501c46096b0283984f6df029495e1abe45dd7475943a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1940190673&rft_id=info:pmid/&rfr_iscdi=true