Effect of ONO-1101, a novel short-acting β-blocker on hemodynamic responses to isoflurane inhalation and tracheal intubation

• Published in: Journal of anesthesia 1998-09, Vol.12 (3), p.115-118
• Main Authors: Hasuo, Hiroshi, Tomiyasu, Shiro, Hojo, Minoru, Fujigaki, Toru, Fukusaki, Makoto, Sumikawa, Koji
• Format: Article
• Language: English
• ISSN: 0913-8668; 1438-8359
• DOI: 10.1007/BF02480087

We investigated the effect of a new ultrashort-acting β-blocker, ONO-1101, on hemodynamic responses to isoflurane inhalation and tracheal intubation. Fifty-four ASA PS 1 or 2 patients were randomly allocated to receive either ONO-1101, 0.04 mg·kg ·min , or saline prior to tracheal intubation. Anesthesia was induced with thiamylal, 4 mg·kg , and vecuronium, 0.15 mg·kg . Tracheal intubation was carried out after 3 min controlled mask ventilation with 66% N O and 3% inspired isoflurane in oxygen. Heart rate and blood pressure were continuously recorded from the start of induction until 5 min after intubation. Plasma concentrations of catecholamines were measured before induction, 3 min after initiating inhalation of isoflurane, and 1 min after tracheal intubation. Significant increases in heart rate occurred in both groups in response to isoflurane inhalation and tracheal intubation, but the magnitude of the increase was significantly less in the ONO-1101 group. Blood pressure increased after tracheal intubation in the saline group but remained unchanged in the ONO-1101 group. Plasma concentrations of norepinephrine increased after induction and intubation in both groups, with no significant difference between the groups. ONO-1101 infusion is effective for the attenuation of hemodynamic responses to isoflurane inhalation and tracheal intubation.