The effect of CGRP-induced hypotension on organ blood flow during halothane anesthesia in dogs: a comparison with trimetaphan

Calcitonin gene-related peptide (CGRP) is an endogenous 37-amino-acid peptide which is a powerful vasodilator of the splanchnic circulation. To elucidate the effects of CGRP-induced hypotension on the organ blood flow, we compared the renal, hepatic, and pancreatic organ flows of CGRP-induced hypote...

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Bibliographic Details
Published in:Journal of anesthesia 1997-09, Vol.11 (3), p.202-207
Main Authors: Takeda, Shohei, Tomaru, Teruaki, Inada, Yutaka
Format: Article
Language:English
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Summary:Calcitonin gene-related peptide (CGRP) is an endogenous 37-amino-acid peptide which is a powerful vasodilator of the splanchnic circulation. To elucidate the effects of CGRP-induced hypotension on the organ blood flow, we compared the renal, hepatic, and pancreatic organ flows of CGRP-induced hypotension with those of trimetaphan (TMP) in halothane-anesthetized dogs. Systemic hemodynamics and organ blood flow were determined in 18 mongrel dogs allocated to one of two groups: CGRP group (n=10) and TMP group (n=8). CGRP of TMP was infused at a rate sufficient to decrease the mean arterial pressure (MAP) to near 60 mmHg from the baseline values for a 60 min-hypotensive period. Organ blood flow was measured using the hydrogen clearance technique. The decrease in MAP was approximately 50% of baseline values (P
ISSN:0913-8668
1438-8359
DOI:10.1007/BF02480038