Reconsidering the classification of tick-borne encephalitis virus within the Siberian subtype gives new insights into its evolutionary history

Tick-borne encephalitis is widespread in Eurasia and transmitted by Ixodes ticks. Classification of its causative agent, tick-borne encephalitis virus (TBEV), includes three subtypes, namely Far-Eastern, European, and Siberian (TBEV-Sib), as well as a group of 886-84-like strains with uncertain taxo...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2017-11, Vol.55, p.159-165
Main Authors: Kovalev, S.Y., Mukhacheva, T.A.
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Classification
Cluster Analysis
Clusteron structure
Encephalitis Viruses, Tick-Borne - classification
Encephalitis Viruses, Tick-Borne - genetics
Evolution, Molecular
Genes, Viral
Genetic Variation
Humans
Phylogenetic lineage
Phylogeny
Phylogeography
RNA, Viral
Siberian subtype
Tick-borne encephalitis virus
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Summary:Tick-borne encephalitis is widespread in Eurasia and transmitted by Ixodes ticks. Classification of its causative agent, tick-borne encephalitis virus (TBEV), includes three subtypes, namely Far-Eastern, European, and Siberian (TBEV-Sib), as well as a group of 886-84-like strains with uncertain taxonomic status. TBEV-Sib is subdivided into three phylogenetic lineages: Baltic, Asian, and South-Siberian. A reason to reconsider TBEV-Sib classification was the analysis of 186 nucleotide sequences of an E gene fragment submitted to GenBank during the last two years. Within the South-Siberian lineage, we have identified a distinct group with prototype strains Aina and Vasilchenko as an individual lineage named East-Siberian. The analysis of reclassified lineages has promoted a new model of the evolutionary history of TBEV-Sib lineages and TBEV-Sib as a whole. Moreover, we present arguments supporting separation of 886-84-like strains into an individual TBEV subtype, which we propose to name Baikalian (TBEV-Bkl). •We have proposed a new phylogenetic lineage within the TBEV-Sib named East-Siberian.•Reasons for separation of 886-84-like strains into Baikalian TBEV subtype are given.•A new evolutionary scenario for TBEV-Sib is proposed.•Baikalian TBEV subtype is likely to originate directly from the Far-Eastern subtype.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2017.09.014