Towards personalized medicine of colorectal cancer

Efforts in colorectal cancer (CRC) research aim to improve early detection and treatment for metastatic stages which could translate into better prognosis of this disease. One of the major challenges that hinder these efforts is the heterogeneous nature of CRC and involvement of diverse molecular pa...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2017-10, Vol.118, p.70-78
Main Authors: Aziz, Mohammad Azhar, Yousef, Zeyad, Saleh, Ayman M., Mohammad, Sameer, Al Knawy, Bandar
Format: Article
Language:English
Subjects:
Colorectal cancer
Colorectal Neoplasms - etiology
Colorectal Neoplasms - genetics
Colorectal Neoplasms - therapy
Genomics
Humans
Metabolomics
Personalized medicine
Precision Medicine
Proteomics
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Transcriptomics
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Summary:Efforts in colorectal cancer (CRC) research aim to improve early detection and treatment for metastatic stages which could translate into better prognosis of this disease. One of the major challenges that hinder these efforts is the heterogeneous nature of CRC and involvement of diverse molecular pathways. New large-scale ‘omics’ technologies are making it possible to generate, analyze and interpret biological data from molecular determinants of CRC. The developments of sophisticated computational analyses would allow information from different omics platforms to be integrated, thus providing new insights into the biology of CRC. Together, these technological advances and an improved mechanistic understanding might allow CRC to be clinically managed at the level of the individual patient. This review provides an account of the current challenges in CRC management and an insight into how new technologies could allow the development of personalized medicine for CRC.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2017.08.007