Secretion and regeneration of tetrodotoxin in the rough-skin newt ( Taricha granulosa)

Rough-skin newts ( Taricha granulosa) released tetrodotoxin (TTX) in their skin secretions in response to mild electric stimulation. This release resulted in a large (21% to almost 90% of the pre-stimulation levels) reduction in the amount of TTX present in the dorsal skin of individual newts. Over...

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Bibliographic Details
Published in:Toxicon (Oxford) 2004-12, Vol.44 (8), p.933-938
Main Authors: Cardall, Brian L., Brodie, Edmund D., Hanifin, Charles T.
Format: Article
Language:English
Subjects:
Animal and plant ecology
Animal, plant and microbial ecology
Animals
Autoecology
Biological and medical sciences
Caudata
Electric Stimulation
Female
Fundamental and applied biological sciences. Psychology
Granular glands
Male
Predator–prey
Regeneration
Reptilia. Amphibia
Salamandridae
Salamandridae - metabolism
Skin - metabolism
Skin - secretion
Taricha granulosa
Tetrodotoxin
Tetrodotoxin - biosynthesis
Tetrodotoxin - secretion
TTX
Vertebrata
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Summary:Rough-skin newts ( Taricha granulosa) released tetrodotoxin (TTX) in their skin secretions in response to mild electric stimulation. This release resulted in a large (21% to almost 90% of the pre-stimulation levels) reduction in the amount of TTX present in the dorsal skin of individual newts. Over the next 9 months newts significantly regenerated the levels of TTX in their skin. These data, in combination with previously published results, are consistent with the hypothesis that these newts produce their own TTX.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2004.09.006