Myelin plasticity, neural activity, and traumatic neural injury

ABSTRACT The possibility that adult organisms exhibit myelin plasticity has recently become a topic of great interest. Many researchers are exploring the role of myelin growth and adaptation in daily functions such as memory and motor learning. Here we consider evidence for three different potential...

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Published in:Developmental neurobiology (Hoboken, N.J.) N.J.), 2018-02, Vol.78 (2), p.108-122
Main Authors: Kondiles, Bethany R., Horner, Philip J.
Format: Article
Language:English
Subjects:
Axons
Demyelination
Glial stem cells
Memory
Motor skill learning
Myelin
myelin plasticity
Myelination
neural activity
neural injury
Oligodendrocytes
Plastic properties
Plasticity
Plasticity (neural)
remyelination
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description ABSTRACT The possibility that adult organisms exhibit myelin plasticity has recently become a topic of great interest. Many researchers are exploring the role of myelin growth and adaptation in daily functions such as memory and motor learning. Here we consider evidence for three different potential categories of myelin plasticity: the myelination of previously bare axons, remodeling of existing sheaths, and the removal of a sheath with replacement by a new internode. We also review evidence that points to the importance of neural activity as a mechanism by which oligodendrocyte precursor cells (OPCs) are cued to differentiate into myelinating oligodendrocytes, which may potentially be an important component of myelin plasticity. Finally, we discuss demyelination in the context of traumatic neural injury and present an argument for altering neural activity as a potential therapeutic target for remyelination following injury. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 108–122, 2018.
doi_str_mv 10.1002/dneu.22540
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subjects Axons
Demyelination
Glial stem cells
Memory
Motor skill learning
Myelin
myelin plasticity
Myelination
neural activity
neural injury
Oligodendrocytes
Plastic properties
Plasticity
Plasticity (neural)
remyelination
title Myelin plasticity, neural activity, and traumatic neural injury
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