Dose escalation intensity-modulated radiotherapy–based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma

No studies have investigated the effects of irradiation-dose escalation intensity-modulated radiotherapy (IMRT)-based concurrent chemoradiotherapy (CCRT) in patients with thoracic esophageal squamous cell carcinoma (TESCC). We analyzed data from patients with TESCC who were enrolled in the Taiwan Ca...

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Bibliographic Details
Published in:Radiotherapy and oncology 2017-10, Vol.125 (1), p.73-79
Main Authors: Chang, Chia-Lun, Tsai, Hsieh-Chih, Lin, Wei-Cheng, Chang, Jer-Hwa, Hsu, Han-Lin, Chow, Jyh-Ming, Yuan, Kevin Sheng-Po, Wu, Alexander T.H., Wu, Szu-Yuan
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Chemoradiotherapy
Cohort Studies
Databases, Factual
Dose escalation
Dose-Response Relationship, Radiation
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - pathology
Esophageal Neoplasms - radiotherapy
Esophageal Squamous Cell Carcinoma
Female
Humans
Intensity-modulated radiotherapy
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Proportional Hazards Models
Radiotherapy, Intensity-Modulated
Squamous cell carcinoma
Thoracic esophageal cancer
Thorax - pathology
Treatment Outcome
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Summary:No studies have investigated the effects of irradiation-dose escalation intensity-modulated radiotherapy (IMRT)-based concurrent chemoradiotherapy (CCRT) in patients with thoracic esophageal squamous cell carcinoma (TESCC). We analyzed data from patients with TESCC who were enrolled in the Taiwan Cancer Registry database. To compare treatment outcomes, the patients were categorized into two groups according to their radiotherapy doses: group 1, who received CCRT
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2017.08.025