Peripheral blood monocytes reveal an activated phenotype in pediatric uveitis

To characterize peripheral blood monocytes in uveitis associated with juvenile idiopathic arthritis (JIAU). Peripheral blood monocytes from children with JIA (either with (n = 18) or without uveitis (n = 11)), idiopathic anterior uveitis (IAU; n = 12) and healthy controls (n = 11) were analyzed by f...

Full description

Saved in:
Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2018-05, Vol.190, p.84-88
Main Authors: Walscheid, Karoline, Neekamp, Lisa, Heiligenhaus, Arnd, Weinhage, Toni, Holzinger, Dirk, Heinz, Carsten, Kasper, Maren, Foell, Dirk
Format: Article
Language:English
Subjects:
Adolescent
Antirheumatic Agents - therapeutic use
Arthritis, Juvenile - blood
Arthritis, Juvenile - drug therapy
Arthritis, Juvenile - immunology
B7-2 Antigen - immunology
B7-2 Antigen - metabolism
Child
Child, Preschool
Female
Humans
Infant
Juvenile arthritis
Lipopolysaccharide Receptors - immunology
Lipopolysaccharide Receptors - metabolism
Male
Methotrexate - therapeutic use
Monocytes
Monocytes - drug effects
Monocytes - immunology
Monocytes - metabolism
Pathogenesis
Therapy
Treatment Outcome
Uveitis
Uveitis - blood
Uveitis - drug therapy
Uveitis - immunology
Uveitis, Anterior - blood
Uveitis, Anterior - drug therapy
Uveitis, Anterior - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To characterize peripheral blood monocytes in uveitis associated with juvenile idiopathic arthritis (JIAU). Peripheral blood monocytes from children with JIA (either with (n = 18) or without uveitis (n = 11)), idiopathic anterior uveitis (IAU; n = 12) and healthy controls (n = 11) were analyzed by flow cytometry. Percentage of CD14 + CD86+ monocytes and CD86 expression on single cell level were significantly higher in all patient groups than in controls, whereas no major differences existed between patient groups. Frequency of CD39+ (p 
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2017.09.014