Localization of Oxytalan Fiber, type III Collagen and BMP Family in Conventional and Desmoplastic Ameloblastoma

The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen an...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2008, Vol.17(1), pp.23-30
Main Authors: Inoue, Masahisa, Nagatsuka, Hitoshi, Tamamura, Ryo, Chong, Huat Siar, Tsujigiwa, Hidetsugu, Borkosky, Silvia, Fujii, Masae, Nagai, Noriyuki, Setsu, Kojun
Format: Article
Language:English
Subjects:
Ameloblastoma
BMP family
Matrix proteins
Odontogenic neoplasm
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Summary:The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen and BMP family in DA (n=8) was compared with CA (n=24), and periodontal ligament (PL) (n=8). Oxytalan fibers formed apico-occlusal bundles in PL, thick radial bundles around tumor nests in DA, and as scanty fibers in CA. Type III collagen was identified in PL, strongly expressed in DA stroma, but weakly in CA. BMP-2, -3, -4 and -7 expression patterns in tumor epithelium and stroma were more pronounced in DA (including sites of bone formation), than CA. No immunoreactivity for BMP-5 and -6 were detected. Current findings suggest that the stroma in DA is neoplastic and derived from odontogenic ectomesenchyme, and recommends its reclassification as an odontogenic epithelial-ectomesenchymal neoplasm.
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.17.23