Preparation and characterization of galactosylated chitosan coated BSA microspheres containing 5-fluorouracil

In this paper, new sustained release microspheres with a surface coating of targeting moieties coating are presented. Bovine serum albumin (BSA) was used to prepare the microspheres loading with 5-fluorouracil (5-FU) by means of chemical crosslinking method and then the microspheres were coated with...

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Bibliographic Details
Published in:Carbohydrate polymers 2008-05, Vol.72 (3), p.390-397
Main Authors: Zhang, Can, Cheng, Yao, Qu, Guowei, Wu, Xiaoli, Ding, Ya, Cheng, Zhihong, Yu, Liangli, Ping, Qineng
Format: Article
Language:English
Subjects:
5-Fluorouracil
Applied sciences
Biological and medical sciences
Bovine serum albumin
chemical analysis
chitosan
Coating
coatings
crosslinking
crystal structure
drug delivery systems
electrostatic interactions
encapsulation
Exact sciences and technology
Galactosylated chitosan
General pharmacology
Medical sciences
Microspheres
Natural polymers
particle size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Proteins
targeted delivery
Targeting delivery
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Summary:In this paper, new sustained release microspheres with a surface coating of targeting moieties coating are presented. Bovine serum albumin (BSA) was used to prepare the microspheres loading with 5-fluorouracil (5-FU) by means of chemical crosslinking method and then the microspheres were coated with N-galactosylated chitosan by electrostatic interaction. The structure of coating layers on the surface of 5-FU-loaded BSA microspheres was characterized by attenuated total reflection Fourier (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA), wide X-ray diffraction (WXRD) and transmission electron microscopy (TEM). The properties of the coated microspheres containing 5-FU were determined. The size was in the range of 0.60–0.65 μm, zeta potential was 16.6 mv, and the encapsulation efficiency, drug loading, and the content of galactosyl groups were 40.3% (w/w), 2.9% (w/w), and 5.4% (w/w), respectively. In comparison with uncoated microspheres, the coated microspheres showed delayed release and less burst release in vitro. All results suggested the BSA microspheres preparation with galactosyl chitosan coating could be a promising method for targeted delivery to the liver.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2007.09.004