Direct Access to Cobaltacycles via C–H Activation: N‑Chloroamide-Enabled Room-Temperature Synthesis of Heterocycles

Cobaltacycle synthesis via C–H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing synthon for cobalt-catalyzed room-temperature C–H activation and construction of heterocycles. Alkynes as coupling...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2017-10, Vol.19 (19), p.5348-5351
Main Authors: Yu, Xiaolong, Chen, Kehao, Guo, Shan, Shi, Pengfei, Song, Chao, Zhu, Jin
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cobaltacycle synthesis via C–H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing synthon for cobalt-catalyzed room-temperature C–H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b02632