Direct Access to Cobaltacycles via C–H Activation: N‑Chloroamide-Enabled Room-Temperature Synthesis of Heterocycles

Cobaltacycle synthesis via C–H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing synthon for cobalt-catalyzed room-temperature C–H activation and construction of heterocycles. Alkynes as coupling...

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Published in:Organic letters 2017-10, Vol.19 (19), p.5348-5351
Main Authors: Yu, Xiaolong, Chen, Kehao, Guo, Shan, Shi, Pengfei, Song, Chao, Zhu, Jin
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Language:English
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cited_by cdi_FETCH-LOGICAL-a411t-6c315d21c908890085606f73e4a05a838c1cef1e1f80b096617cb5cb714889773
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container_title Organic letters
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creator Yu, Xiaolong
Chen, Kehao
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Shi, Pengfei
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description Cobaltacycle synthesis via C–H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing synthon for cobalt-catalyzed room-temperature C–H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.
doi_str_mv 10.1021/acs.orglett.7b02632
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title Direct Access to Cobaltacycles via C–H Activation: N‑Chloroamide-Enabled Room-Temperature Synthesis of Heterocycles
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