The WHO Classification of Tumors of the Nervous System

The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor,...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2002-03, Vol.61 (3), p.215-225
Main Authors: KLEIHUES, PAUL, LOUIS, DAVID N, SCHEITHAUER, BERND W, RORKE, LUCY B, REIFENBERGER, GUIDO, BURGER, PETER C, CAVENEE, WEBSTER K
Format: Article
Language:English
Subjects:
Humans
Nervous System Neoplasms - classification
Nervous System Neoplasms - pathology
Nervous System Neoplasms - therapy
Prognosis
World Health Organization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/61.3.215