Expression of p73 in normal skin and proliferative skin lesions

The p73 gene is a member of the p53 gene family and the structure and functions of p73 protein are similar to those of  p53.  However,  these  two  proteins  have  different  roles. In the present study, p73 protein was found immunohistochemically to be distributed in the basal cells of the epidermi...

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Bibliographic Details
Published in:Pathology international 2004-12, Vol.54 (12), p.890-895
Main Authors: Kamiya, Makoto, Takeuchi, Yuko, Katho, Mari, Yokoo, Hideaki, Sasaki, Atsushi, Nakazato, Yoichi
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
carcinogenesis
Carcinoma, Basal Cell - metabolism
Carcinoma, Basal Cell - pathology
Cell Proliferation
differentiation
DNA-Binding Proteins - biosynthesis
Genes, Tumor Suppressor
Humans
Immunohistochemistry
Keratosis, Seborrheic - metabolism
Keratosis, Seborrheic - pathology
Ki-67 Antigen - metabolism
Neoplasms, Squamous Cell - metabolism
Neoplasms, Squamous Cell - pathology
Nuclear Proteins - biosynthesis
p53
p73
skin
Skin - metabolism
Skin Diseases - metabolism
Skin Diseases - pathology
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Tumor Protein p73
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Proteins
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Summary:The p73 gene is a member of the p53 gene family and the structure and functions of p73 protein are similar to those of  p53.  However,  these  two  proteins  have  different  roles. In the present study, p73 protein was found immunohistochemically to be distributed in the basal cells of the epidermis, columnar basal cells in the hair follicle and peripheral cells without lipid droplets in the sebaceous and meibomian glands; it was expressed strongly in tumor cells in basal cell carcinomas and in the basal cell‐like cells in seborrheic keratosis, and weakly or negatively in the squamous cell‐like cells in seborrheic keratosis and in the tumor cells in squamous cell carcinomas. No relationship was detected between p73 and p53 protein distribution and between p73 protein expression and the proliferative potential, as shown by the Ki‐67 immunopositive cell ratio. The present study shows that p73 protein is likely to play important roles in skin differentiation rather than proliferation or carcinogenesis of the skin.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2004.01777.x