Readressing the Role of Toll-Like Receptor-4 Alleles in Inflammatory Bowel Disease: Colitis, Smoking, and Seroreactivity

Background Toll-like receptor ( TLR ) polymorphisms, and especially TLR - 4 Asp299Gly and TLR - 4 Thr399Ile , have been linked with Crohn’s disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens. Available data, however, ar...

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Bibliographic Details
Published in:Digestive diseases and sciences 2013-02, Vol.58 (2), p.371-380
Main Authors: Manolakis, Anastassios C., Kapsoritakis, Andreas N., Kapsoritaki, Anastasia, Tiaka, Elisavet K., Oikonomou, Konstantinos A., Lotis, Vassilis, Vamvakopoulou, Dimitra, Davidi, Ioanna, Vamvakopoulos, Nikolaos, Potamianos, Spyros P.
Format: Article
Language:English
Subjects:
Adult
Aged
Biochemistry
C-Reactive Protein - metabolism
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - genetics
Colitis, Ulcerative - immunology
Crohn Disease - epidemiology
Crohn Disease - genetics
Crohn Disease - immunology
Disaccharides - immunology
Female
Gastroenterology
Gene Frequency
Genotype
Hepatology
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Inflammatory bowel disease
Male
Mannans - immunology
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Polymorphism, Single Nucleotide - genetics
Polymorphism, Single Nucleotide - immunology
Saccharomyces cerevisiae - immunology
Seroepidemiologic Studies
Smoking - epidemiology
Smoking - genetics
Smoking - immunology
Toll-Like Receptor 4 - genetics
Toll-Like Receptor 4 - immunology
Transplant Surgery
Young Adult
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Summary:Background Toll-like receptor ( TLR ) polymorphisms, and especially TLR - 4 Asp299Gly and TLR - 4 Thr399Ile , have been linked with Crohn’s disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens. Available data, however, are conflicting. Aims To address these issues, the distribution of TLR - 4 polymorphic alleles was assessed in patients with UC, CD, and healthy controls (HC), considering patient and disease characteristics as well as related serological markers. Methods TLR - 4 Asp299Gly and TLR - 4 Thr399Ile polymorphisms were determined in 187 UC and 163 CD patients and 274 randomly selected HC. C reactive protein, anti- Saccharomyces cerevisiae mannan antibodies, anti-mannobioside carbohydrate antibodies, anti-laminariobioside carbohydrate antibodies IgG, and anti-chitobioside carbohydrate antibodies (ACCA) IgA levels were also assessed. Results UC and especially pancolitis patients carried the mutant alleles more frequently compared to CD patients and HC or UC patients with different disease extents ( P  = 0.002 and P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-012-2348-4