Association of Serotonin Transporter Promoter Polymorphism (5-HTTLPR) with Microscopic Colitis and Ulcerative Colitis

Background Serotonin (5-HT) release and serotonin reuptake transporter (5-HTT) expression have been reported to be decreased in experimental colitis, in interleukin-10 knockout-associated colitis, and in patients with ulcerative colitis. Serotonin is known to play an important role in the pathogenes...

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Published in:Digestive diseases and sciences 2015-04, Vol.60 (4), p.887-894
Main Authors: Sikander, Arbab, Sinha, Saroj Kant, Prasad, Kaushal Kishor, Rana, Satya Vati
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biochemistry
Case-Control Studies
Colitis, Microscopic - blood
Colitis, Microscopic - genetics
Colitis, Ulcerative - blood
Colitis, Ulcerative - genetics
Female
Gastroenterology
Genes
Genetic aspects
Genetic polymorphisms
Hepatology
Humans
Interleukins
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Phenols
Pneumoviridae
Polymorphism, Genetic
Promoter Regions, Genetic
Prospective Studies
Serotonin
Serotonin - blood
Serotonin Plasma Membrane Transport Proteins - genetics
Sex Factors
Transplant Surgery
Ulcerative colitis
Young Adult
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Summary:Background Serotonin (5-HT) release and serotonin reuptake transporter (5-HTT) expression have been reported to be decreased in experimental colitis, in interleukin-10 knockout-associated colitis, and in patients with ulcerative colitis. Serotonin is known to play an important role in the pathogenesis of colitis, but individual genetic variants of 5-HTT gene in microscopic colitis and ulcerative colitis are not known. Aim This study aimed to evaluate the association between the serotonin transporter gene promoter polymorphism (5-HTTLPR) and 5-HT concentration in microscopic colitis (MC) and ulcerative colitis (UC) patients. Method This prospective case–control study included 41 patients with microscopic colitis (age 19–82 years, mean 35 ± 13.6), 75 patients with ulcerative colitis (age 16–65 years, mean 38.5 ± 11.6), and 100 controls (age 20–64 years, mean 38 ± 11). 5-HTTLPR gene polymorphism was studied by polymerase chain reaction-based assay. 5-HT levels were measured by ELISA. Results The frequency of the 5-HTTLPR (SS) genotype was significantly lower in MC (12 %) patients compared to controls (30 %) ( p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-014-3482-y