Cardiovascular Disease and Myocardial Abnormalities in Nonalcoholic Fatty Liver Disease

• Published in: Digestive diseases and sciences 2016-05, Vol.61 (5), p.1246-1267
• Main Authors: Mantovani, Alessandro, Ballestri, Stefano, Lonardo, Amedeo, Targher, Giovanni
• Format: Article
• Language: English
• Subjects: Biochemistry; Cardiovascular Diseases - complications; Cardiovascular Diseases - pathology; Coronary heart disease; Development and progression; Fatty liver; Gastroenterology; Heart; Hepatology; Humans; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Myocardium - pathology; Non-alcoholic Fatty Liver Disease - complications; Oncology; Pneumoviridae; Review; Transplant Surgery; Type 2 diabetes
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-016-4040-6

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in many developed countries, affecting an estimated 30 % of the adult population. In this updated clinical review, we summarize the current knowledge regarding the strong association between NAFLD and the risk of coronary heart disease (CHD) and other functional, structural, and arrhythmic cardiac complications (e.g., left ventricular dysfunction, heart valve diseases and atrial fibrillation). We also briefly discuss the putative biological mechanisms linking NAFLD with these important extra-hepatic complications. To date, a large body of evidence has suggested that NAFLD is not simply a marker of CHD and other functional, structural, and arrhythmic cardiac complications, but also may play a part in the development and progression of these cardiac complications. The clinical implication of these findings is that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions aimed at decreasing the risk of CHD and other cardiac and arrhythmic complications.