Universal Versus Targeted Screening for Lynch Syndrome: Comparing Ascertainment and Costs Based on Clinical Experience

Background Strategies to screen colorectal cancers (CRCs) for Lynch syndrome are evolving rapidly; the optimal strategy remains uncertain. Aim We compared targeted versus universal screening of CRCs for Lynch syndrome. Methods In 2010–2011, we employed targeted screening (age 

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Bibliographic Details
Published in:Digestive diseases and sciences 2016-10, Vol.61 (10), p.2887-2895
Main Authors: Erten, Mujde Z., Fernandez, Luca P., Ng, Hank K., McKinnon, Wendy C., Heald, Brandie, Koliba, Christopher J., Greenblatt, Marc S.
Format: Article
Language:English
Subjects:
Age Factors
Biochemistry
Cancer
Colonoscopy - economics
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - economics
Colorectal Neoplasms - genetics
Colorectal Neoplasms - prevention & control
Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis - economics
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Comparative analysis
Diagnosis
DNA Mismatch Repair - genetics
DNA-Binding Proteins - genetics
Early Detection of Cancer
Economic aspects
Gastroenterology
Gene mutations
Genetic screening
Genetic Testing - economics
Germ-Line Mutation
Health Care Costs
Hepatology
Humans
Immunohistochemistry
Immunohistochemistry - economics
Mass Screening - economics
Medical colleges
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Mismatch Repair Endonuclease PMS2 - genetics
MutL Protein Homolog 1 - genetics
MutS Homolog 2 Protein - genetics
Oncology
Original Article
Patient Selection
Pneumoviridae
Proteins
Systems Analysis
Transplant Surgery
United States
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Description
Summary:Background Strategies to screen colorectal cancers (CRCs) for Lynch syndrome are evolving rapidly; the optimal strategy remains uncertain. Aim We compared targeted versus universal screening of CRCs for Lynch syndrome. Methods In 2010–2011, we employed targeted screening (age 
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-016-4218-y