Gut Microbiota of Nonalcoholic Fatty Liver Disease

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on de...

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Bibliographic Details
Published in:Digestive Diseases and Sciences 2016-05, Vol.61 (5), p.1268-1281
Main Authors: Abdou, Reham M., Zhu, Lixin, Baker, Robert D., Baker, Susan S.
Format: Article
Language:English
Subjects:
Biochemistry
Fatty liver
Gastroenterology
Gastrointestinal diseases
Gastrointestinal Tract - microbiology
Hepatology
Humans
Inflammation - microbiology
Liver Cirrhosis - microbiology
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Microbiota (Symbiotic organisms)
Non-alcoholic Fatty Liver Disease - microbiology
Oncology
Review
Transplant Surgery
Transplantation of organs, tissues, etc
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Summary:The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-016-4045-1