Guidelines versus real life practice: the case of colonoscopy in acromegaly

Purpose The aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly. Methods We conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We eva...

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Bibliographic Details
Published in:Pituitary 2018-02, Vol.21 (1), p.16-24
Main Authors: Parolin, M., Dassie, F., Russo, L., Mazzocut, S., Ferrata, M., De Carlo, E., Mioni, R., Fallo, F., Vettor, R., Martini, C., Maffei, P.
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - blood
Acromegaly - diagnosis
Acromegaly - epidemiology
Adenomatous Polyps - blood
Adenomatous Polyps - epidemiology
Adenomatous Polyps - pathology
Adult
Aged
Chi-Square Distribution
Colon
Colon - pathology
Colonic Neoplasms - blood
Colonic Neoplasms - epidemiology
Colonic Neoplasms - pathology
Colonic Polyps - blood
Colonic Polyps - epidemiology
Colonic Polyps - pathology
Colonoscopy
Colonoscopy - standards
Cross-Sectional Studies
Data processing
Diagnosis
Endocrinology
Female
Growth hormones
Guideline Adherence
Human Physiology
Humans
Insulin
Insulin-like growth factor I
Italy - epidemiology
Male
Medicine
Medicine & Public Health
Middle Aged
Odds Ratio
Polyps
Practice Guidelines as Topic - standards
Predictive Value of Tests
Prevalence
Retrospective Studies
Risk Factors
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Summary:Purpose The aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly. Methods We conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values. Results The total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990–1994 to 57 in the period 2010–2014. Colonoscopy procedures were performed according to guidelines in 25% of ACRO patients at diagnosis, 51% at follow-up and 11% globally (both at diagnosis and follow-up). Among the 146 ACRO patients, 68% were subjected to at least one colonoscopy and in 32% of the cases a polyp was detected during the procedure. The presence of polyps was significantly associated with mean levels of growth hormone (GH), insulin-like growth factor 1 (IGF-1), fasting glucose and insulin levels (p 
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-017-0841-7