Venous thromboembolism in children with cystic fibrosis: Retrospective incidence and intrapopulation risk factors

Pediatric venous thromboembolism (VTE) is a rare but serious medical condition. Cystic fibrosis (CF) is a risk for recurrent pediatric VTE and has potential thrombophilic tendency. However, much remains unknown, including incidence and intrapopulation risk factors. A retrospective cohort of pediatri...

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Bibliographic Details
Published in:Thrombosis research 2017-10, Vol.158, p.161-166
Main Authors: Knight-Perry, Jessica, Branchford, Brian R., Thornhill, Dianne, Martiniano, Stacey L., Sagel, Scott D., Wang, Michael
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - pathology
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Pediatric
Retrospective Studies
Risk Factors
Risk stratification
Venous thromboembolism
Venous Thromboembolism - etiology
Venous Thromboembolism - pathology
Young Adult
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Summary:Pediatric venous thromboembolism (VTE) is a rare but serious medical condition. Cystic fibrosis (CF) is a risk for recurrent pediatric VTE and has potential thrombophilic tendency. However, much remains unknown, including incidence and intrapopulation risk factors. A retrospective cohort of pediatric CF patients followed at Children's Hospital Colorado from January 1st 2003 through May 20th 2016 was examined. Cases were identified by informatics and validated manually. Data on CF severity, co-morbidities and treatment, central venous catheter (CVC) use, and thrombophilia were obtained from an institutional CF database and chart review. Nineteen VTE occurred in 458 participants followed for 3595 person-years, yielding an incidence rate of 53 VTE per 10,000 children with CF. VTE cases had additional co-morbidities including CF-related diabetes (p=0.002) and sinus disease (p=0.04), more total admissions (p
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2017.08.022