Transporter engineering in biomass utilization by yeast

Abstract Biomass resources are attractive carbon sources for bioproduction because of their sustainability. Many studies have been performed using biomass resources to produce sugars as carbon sources for cell factories. Expression of biomass hydrolyzing enzymes in cell factories is an important app...

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Bibliographic Details
Published in:FEMS yeast research 2017-11, Vol.17 (7)
Main Authors: Hara, Kiyotaka Y., Kobayashi, Jyumpei, Yamada, Ryosuke, Sasaki, Daisuke, Kuriya, Yuki, Hirono-Hara, Yoko, Ishii, Jun, Araki, Michihiro, Kondo, Akihiko
Format: Article
Language:English
Subjects:
Biological Transport
Biomass
Carbohydrate Metabolism
Carbon sources
Clonal deletion
Enzymes
Fermentation
Gene deletion
Gene expression
Genetic engineering
Hydrolysis
Membrane Transport Proteins - genetics
Membrane Transport Proteins - metabolism
Metabolic Engineering
Metabolic pathways
Protein Engineering
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Sugar
Sugars - metabolism
Yeasts - genetics
Yeasts - metabolism
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Summary:Abstract Biomass resources are attractive carbon sources for bioproduction because of their sustainability. Many studies have been performed using biomass resources to produce sugars as carbon sources for cell factories. Expression of biomass hydrolyzing enzymes in cell factories is an important approach for constructing biomass-utilizing bioprocesses because external addition of these enzymes is expensive. In particular, yeasts have been extensively engineered to be cell factories that directly utilize biomass because of their manageable responses to many genetic engineering tools, such as gene expression, deletion and editing. Biomass utilizing bioprocesses have also been developed using these genetic engineering tools to construct metabolic pathways. However, sugar input and product output from these cells are critical factors for improving bioproduction along with biomass utilization and metabolic pathways. Transporters are key components for efficient input and output activities. In this review, we focus on transporter engineering in yeast to enhance bioproduction from biomass resources. The focus in this review is engineering of transporters involved in sugar input and product output from yeast cell factories for improving bioproduction along with biomass utilization and metabolic pathways.
ISSN:1567-1364
1567-1356
1567-1364
DOI:10.1093/femsyr/fox061