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The haemostatic efficacy and foreign body reaction of epinephrine–Impregnated polyurethane foam in osseous defects

The objective of this study was to compare the haemostatic efficacy and foreign body reaction of epinephrine–impregnated cotton pellets with those of epinephrine‐impregnated polyurethane (PU) foam cubes in osseous defects created in guinea pigs. Initially, these substances were randomly applied to t...

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Published in:	Australian endodontic journal 2018-12, Vol.44 (3), p.204-207
Main Authors:	Torabinejad, Mahmoud, Kang, Hyun J. S., Maskiewicz, Richard, Grandhi, Anupama
Format:	Article
Language:	English
Subjects:	Animals apical surgery Chi-Square Distribution Cotton Data processing Defects Dental Implantation, Endosseous, Endodontic - adverse effects Dental Implantation, Endosseous, Endodontic - methods Dentistry Disease Models, Animal Endodontics Epinephrine Epinephrine - administration & dosage foam foreign body reaction Foreign-Body Reaction - therapy Guinea Pigs haemostatic Hemorrhage - prevention & control Hemostatic Techniques impregnated polyurethane Male Polyurethane Polyurethanes Random Allocation Surgery Surgical Sponges Treatment Outcome
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container_title	Australian endodontic journal
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creator	Torabinejad, Mahmoud Kang, Hyun J. S. Maskiewicz, Richard Grandhi, Anupama
description	The objective of this study was to compare the haemostatic efficacy and foreign body reaction of epinephrine–impregnated cotton pellets with those of epinephrine‐impregnated polyurethane (PU) foam cubes in osseous defects created in guinea pigs. Initially, these substances were randomly applied to the osseous defects in guinea pigs for 2 min and blood loss was measured. The animals were then sacrificed 7 weeks later and the degree of foreign body reaction was scored. The data were analysed by the independent‐samples Kruskal‐Wallis test. Epinephrine‐impregnated PU foam cubes showed significantly better haemostatic effect compared to epinephrine–impregnated cotton pellets. The PU foam containing epinephrine specimens elicited significantly less foreign body reaction compared to epinephrine cotton pellets (P
doi_str_mv	10.1111/aej.12234
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The PU foam containing epinephrine specimens elicited significantly less foreign body reaction compared to epinephrine cotton pellets (P < 0.05). Based on the results of this study, it is concluded that epinephrine‐impregnated PU foam cubes are a good alternative to epinephrine‐impregnated cotton pellets as a local haemostatic agent in endodontic surgery.</description><identifier>ISSN: 1329-1947</identifier><identifier>EISSN: 1747-4477</identifier><identifier>DOI: 10.1111/aej.12234</identifier><identifier>PMID: 28940453</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Animals ; apical surgery ; Chi-Square Distribution ; Cotton ; Data processing ; Defects ; Dental Implantation, Endosseous, Endodontic - adverse effects ; Dental Implantation, Endosseous, Endodontic - methods ; Dentistry ; Disease Models, Animal ; Endodontics ; Epinephrine ; Epinephrine - administration & dosage ; foam ; foreign body reaction ; Foreign-Body Reaction - therapy ; Guinea Pigs ; haemostatic ; Hemorrhage - prevention & control ; Hemostatic Techniques ; impregnated polyurethane ; Male ; Polyurethane ; Polyurethanes ; Random Allocation ; Surgery ; Surgical Sponges ; Treatment Outcome</subject><ispartof>Australian endodontic journal, 2018-12, Vol.44 (3), p.204-207</ispartof><rights>2017 Australian Society of Endodontology Inc</rights><rights>2017 Australian Society of Endodontology Inc.</rights><rights>Copyright © 2018 Australian Society of Endodontology Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3134-322ecc9e5c302063a347a28468620963eea66ea01aca6c205d3c5e67e84a9e873</cites><orcidid>0000-0002-1340-0439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28940453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torabinejad, Mahmoud</creatorcontrib><creatorcontrib>Kang, Hyun J. 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subjects	Animals apical surgery Chi-Square Distribution Cotton Data processing Defects Dental Implantation, Endosseous, Endodontic - adverse effects Dental Implantation, Endosseous, Endodontic - methods Dentistry Disease Models, Animal Endodontics Epinephrine Epinephrine - administration & dosage foam foreign body reaction Foreign-Body Reaction - therapy Guinea Pigs haemostatic Hemorrhage - prevention & control Hemostatic Techniques impregnated polyurethane Male Polyurethane Polyurethanes Random Allocation Surgery Surgical Sponges Treatment Outcome
title	The haemostatic efficacy and foreign body reaction of epinephrine–Impregnated polyurethane foam in osseous defects
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