The role of the immune system in Alzheimer disease: Etiology and treatment

The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous system immune components, such as complement and m...

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Bibliographic Details
Published in:Ageing research reviews 2017-11, Vol.40, p.84-94
Main Authors: Jevtic, Stefan, Sengar, Ameet S, Salter, Michael W, McLaurin, JoAnne
Format: Article
Language:English
Subjects:
Alzheimer Disease - etiology
Alzheimer Disease - immunology
Alzheimer Disease - therapy
Brain - drug effects
Brain - immunology
Complement System Proteins - immunology
Humans
Immune System - drug effects
Immune System - immunology
Immunity, Cellular - drug effects
Immunity, Cellular - immunology
Immunity, Innate - drug effects
Immunity, Innate - immunology
Immunotherapy - methods
Microglia - drug effects
Microglia - immunology
Treatment Outcome
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Summary:The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous system immune components, such as complement and microglia, as well as novel aspects of the peripheral immune system that can influence disease, such as monocytes and lymphocytes. By detailing the roles of various immune cells in AD, we summarize an emerging perspective for disease etiology and future therapeutic targets.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2017.08.005