Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

•Striatonigral pathway activation induces repetitive behaviors.•This manipulation induced a wide range of complex behaviors.•Repetition of this manipulation induced long lasting repetitive behav•iors. Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rod...

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Bibliographic Details
Published in:Neuroscience research 2018-07, Vol.132, p.53-57
Main Authors: Bouchekioua, Youcef, Tsutsui-Kimura, Iku, Sano, Hiromi, Koizumi, Miwako, Tanaka, Kenji F., Yoshida, Keitaro, Kosaki, Yutaka, Watanabe, Shigeru, Mimura, Masaru
Format: Article
Language:English
Subjects:
Autistic spectrum disorder (ASD)
D1-MSNs
Direct pathway
Obsessive-compulsive spectrum disorders (OCSD)
Optogenetics
Repetitive behaviors
Striato-nigral pathway
Tourette syndrom
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Summary:•Striatonigral pathway activation induces repetitive behaviors.•This manipulation induced a wide range of complex behaviors.•Repetition of this manipulation induced long lasting repetitive behav•iors. Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2017.09.007