Efficacy of switching to dolutegravir plus rilpivirine, the small-tablet regimen, in patients with dysphagia: two case reports

BACKGROUNDThe advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The number of HIV-1 infected patients who experience difficulty in swallowing tablet...

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Bibliographic Details
Published in:Journal of pharmaceutical health care and sciences 2017, Vol.3, p.23-23
Main Authors: Suzuki, Takefumi, Hara, Nobuko, Osa, Morichika, Misawa, Kazuhisa, Imai, Kazuo, Fujikura, Yuji, Maeda, Takuya, Sonehara, Wataru, Kawana, Akihiko
Format: Report
Language:English
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Summary:BACKGROUNDThe advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The number of HIV-1 infected patients who experience difficulty in swallowing tablets is expected to increase as the HIV-infected population advances in age or develops comorbidities or treatment sequelae affecting the central nervous system. CASE PRESENTATIONHere, we describe two HIV-1-infected patients who experienced progressive dysphagia leading to inability to swallow the antiretroviral tablets included in the standard regimen. Both patients had a plasma viral load
ISSN:2055-0294
2055-0294
DOI:10.1186/s40780-017-0093-8