Conjugated fatty acid-rich oil from Gynostrmma pentaphyllum seed can ameliorate lipid and glucose metabolism in type 2 diabetes mellitus mice

• Published in: Food & function 2017-10, Vol.8 (10), p.3696-3706
• Main Authors: Zhang, Mingxing, Du, Nan, Wang, Lu, Wang, Xiaobing, Xiao, Yaping, Zhang, Kun, Liu, Quanhong, Wang, Pan
• Format: Article
• Language: English
• Subjects: Animals; Arteriosclerosis; Atherosclerosis; Blood Glucose - metabolism; Cucurbitaceae - chemistry; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat - adverse effects; Fatty acids; Fatty Acids - administration & dosage; Glucose; Glucose metabolism; Glucose tolerance; Glucose transporter; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; High fat diet; Humans; Hyperglycemia; Hyperlipidemia; Hypertension; Insulin; Insulin - metabolism; Insulin Resistance; Isomers; Linolenic acid; Lipid metabolism; Liver; Liver - metabolism; Male; Metabolic syndrome; Metabolism; Mice; Muscles; Oils & fats; Plant Extracts - administration & dosage; Rodents; Seeds; Seeds - chemistry; Skeletal muscle; Streptozocin
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/c7fo00712d

Gynostrmma pentaphyllum seed oil (GPSO), extracted from G. pentaphyllum seeds, is rich in conjugated linolenic acid, which is a special fatty acid consisting of cis-9, trans-11, trans-13 isomers. Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from insulin resistance, and is usually accompanied by hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic syndrome, or syndrome X), and polycystic ovarian disease. This study aimed to investigate the effect of GPSO on T2DM hepatic lipid metabolism and the underlying mechanism involving level of protein expression. In the experiment, the model of T2DM was established. Kunming male mice were fed with a high-fat diet and injected with streptozocin, in which the exploration of detailed mechanism in the therapy of T2DM was targeted. The results showed that the ability of oral glucose tolerance was improved in the GPSO group. Biochemical indices also revealed that GPSO had a positive effect on hypoglycemic activity, suggesting that GPSO could promote the expression of glucose transporter 4 in liver and skeletal muscle.