MicroRNAs in Heart Failure, Cardiac Transplantation, and Myocardial Recovery: Biomarkers with Therapeutic Potential

Purpose of Review Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and ar...

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Bibliographic Details
Published in:Current heart failure reports 2017-12, Vol.14 (6), p.454-464
Main Authors: Shah, Palak, Bristow, Michael R., Port, J. David
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Cardiac Surgery
Cardiology
Heart Failure - genetics
Heart Failure - metabolism
Heart Failure - surgery
Heart Transplantation
Heart-Assist Devices
Humans
Imaging
Internal Medicine
Medicine
Medicine & Public Health
MicroRNAs - metabolism
Myocardium - metabolism
Pharmacologic Therapy (W H W Tang
Radiology
Section Editor
Topical Collection on Pharmacologic Therapy
Vascular Surgery
Ventricular Remodeling
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Summary:Purpose of Review Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and are found in the circulation serving as a biomarker of heart failure. Recent Findings Data suggests that microRNAs may be used to detect allograft rejection in cardiac transplantation and may predict the degree of myocardial recovery in patients with a left ventricular assist device or treated with beta-blocker therapy. Given their role in regulating cellular function, microRNAs are an intriguing target for oligonucleotide therapeutics, designed to mimic or antagonize (antagomir) their biological effects. Summary We review the current state of microRNAs as biomarkers of heart failure and associated conditions, the mechanisms by which microRNAs control cellular function, and how specific microRNAs may be targeted with novel therapeutics designed to treat heart failure.
ISSN:1546-9530
1546-9549
DOI:10.1007/s11897-017-0362-8