J Curve in Patients Randomly Assigned to Different Systolic Blood Pressure Targets: An Experimental Approach to an Observational Paradigm

BACKGROUND:Low systolic blood pressure (SBP) values are associated with an increased risk of cardiovascular events, giving rise to the so-called J-curve phenomenon. We assessed the association between on-treatment SBP levels, cardiovascular events, and all-cause mortality in patients randomized to d...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2017-12, Vol.136 (23), p.2220-2229
Main Authors: Kalkman, Deborah N, Brouwer, Tom F, Vehmeijer, Jim T, Berger, Wouter R, Knops, Reinoud E, de Winter, Robbert J, Peters, Ron J, van den Born, Bert-Jan H
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Cause of Death
Female
Humans
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - mortality
Hypertension - physiopathology
Male
Middle Aged
Risk Assessment
Risk Factors
Systole
Time Factors
Treatment Outcome
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND:Low systolic blood pressure (SBP) values are associated with an increased risk of cardiovascular events, giving rise to the so-called J-curve phenomenon. We assessed the association between on-treatment SBP levels, cardiovascular events, and all-cause mortality in patients randomized to different SBP targets. METHODS:Data from 2 large randomized trials that randomly allocated hypertensive patients at high risk for cardiovascular disease to intensive (SBP
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.117.030342