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Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia
Purpose The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2). Materials and Methods Seventy...
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| Published in: | Journal of clinical ultrasound 2018-01, Vol.46 (1), p.41-47 |
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| container_title | Journal of clinical ultrasound |
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| creator | Sreter, Katherina Bernadette Budimir, Ivan Golub, Andrija Dorosulić, Zdravko Sabol Pušić, Mateja Boban, Marko |
| description | Purpose
The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2).
Materials and Methods
Seventy‐five consecutive adult patients hospitalized for treatment of CAP were recruited in this single‐center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists. Follow‐up assessment was performed within 2 to 4 weeks of ending antibiotic treatment at radiographic resolution of CAP. Fifteen patients were excluded during follow‐up due to confirmation of chronic obstructive pulmonary disease.
Results
Pneumonia was unilateral in 40 (66.7%) and bilateral in 20 (33.3%) patients. Radiographic extent of pneumonia involved 2 pulmonary segments in 31 patients (51.7%), 3 to 5 pulmonary segments in 25 (41.7%), and 6 pulmonary segments in 4 patients (6.6%). ΔPASP between hospital admission and follow‐up correlated with the number of pulmonary segments involved (Rho = 0.953; P |
| doi_str_mv | 10.1002/jcu.22523 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1942708099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1942708099</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-6fda86a189f39e53a29ce7eb2a95758a6b588ebf1ceb0cf508fc35b7c4e14afa3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS0EopfCghdAltjAIq3txEm8RFeUH1ViQ9fRxJnc6yvHTu245e54hO55O54ElxQWSKzOLL5zZjSHkJecnXHGxPlBpzMhpCgfkQ1nqikYU_VjssnCC9FIfkKexXhgjNVSyqfkRLSqYpXgG_Jjuwe3w0iNo3Oyk3cQjhTCglniMS7eGk3ngDGmgFT7ENDCgvTWLHsaYDB-F2DeZyjiDQazZLcb6JzHeY8BLPXfjjt0sBjv7rfAkOwSV7_205Rc9vz8fgf6OpmA2eow5TsMPCdPRrARXzzoKbm6eP91-7G4_PLh0_bdZaFLWZZFPQ7Q1sBbNZYKZQlCaWywF6BkI1uoe9m22I9cY8_0KFk7ZmPf6Ap5BSOUp-TNmjsHf50wLt1kokZrwaFPseOqEg1rmVIZff0PevApuHxdppqGq1bUTaberpQOPsaAYzcHM-XHdpx19411ubHud2OZffWQmPoJh7_kn4oycL4Ct8bi8f9J3eft1Rr5C1zHpjo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977198267</pqid></control><display><type>article</type><title>Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia</title><source>Wiley</source><creator>Sreter, Katherina Bernadette ; Budimir, Ivan ; Golub, Andrija ; Dorosulić, Zdravko ; Sabol Pušić, Mateja ; Boban, Marko</creator><creatorcontrib>Sreter, Katherina Bernadette ; Budimir, Ivan ; Golub, Andrija ; Dorosulić, Zdravko ; Sabol Pušić, Mateja ; Boban, Marko</creatorcontrib><description>Purpose
The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2).
Materials and Methods
Seventy‐five consecutive adult patients hospitalized for treatment of CAP were recruited in this single‐center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists. Follow‐up assessment was performed within 2 to 4 weeks of ending antibiotic treatment at radiographic resolution of CAP. Fifteen patients were excluded during follow‐up due to confirmation of chronic obstructive pulmonary disease.
Results
Pneumonia was unilateral in 40 (66.7%) and bilateral in 20 (33.3%) patients. Radiographic extent of pneumonia involved 2 pulmonary segments in 31 patients (51.7%), 3 to 5 pulmonary segments in 25 (41.7%), and 6 pulmonary segments in 4 patients (6.6%). ΔPASP between hospital admission and follow‐up correlated with the number of pulmonary segments involved (Rho = 0.953; P < .001) and PaO2 (Rho = −0.667; P < .001). The maximum PASP was greater during pneumonia than after resolution (34.82 ± 3.96 vs. 22.67 ± 4.04, P < .001).
Conclusions
Changes in PASP strongly correlated with radiological severity of CAP and PaO2. During pneumonia, PASP appeared increased without significant change in left ventricular filling pressures. This suggests that disease‐related changes in lung tissue caused by pneumonia may easily and reproducibly be assessed using conventional noninvasive bedside diagnostics such as echocardiography and arterial blood gas analysis.</description><identifier>ISSN: 0091-2751</identifier><identifier>EISSN: 1097-0096</identifier><identifier>DOI: 10.1002/jcu.22523</identifier><identifier>PMID: 28940421</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Adults ; Aged ; Antibiotics ; arterial blood gas ; Blood gas analysis ; Blood pressure ; Chronic obstructive pulmonary disease ; Cohort Studies ; Communities ; Community-Acquired Infections - diagnostic imaging ; Community-Acquired Infections - physiopathology ; community‐acquired pneumonia ; Correlation ; Doppler effect ; Echocardiography ; Echocardiography, Doppler ; Female ; Gas analysis ; Heart ; Humans ; Lung diseases ; Male ; Middle Aged ; Obstructive lung disease ; Oxygen - blood ; Oxygenation ; Partial Pressure ; Patients ; Peripheral blood ; Pneumonia ; Pneumonia - blood ; Pneumonia - diagnostic imaging ; Pneumonia - physiopathology ; Prospective Studies ; Pulmonary arteries ; Pulmonary artery ; Pulmonary Artery - diagnostic imaging ; Pulmonary Artery - physiopathology ; pulmonary artery systolic pressure ; respiratory dynamics ; Segments ; Systolic pressure ; Ultrasonic imaging ; Ventricle</subject><ispartof>Journal of clinical ultrasound, 2018-01, Vol.46 (1), p.41-47</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-6fda86a189f39e53a29ce7eb2a95758a6b588ebf1ceb0cf508fc35b7c4e14afa3</citedby><cites>FETCH-LOGICAL-c3533-6fda86a189f39e53a29ce7eb2a95758a6b588ebf1ceb0cf508fc35b7c4e14afa3</cites><orcidid>0000-0002-1671-5540</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28940421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sreter, Katherina Bernadette</creatorcontrib><creatorcontrib>Budimir, Ivan</creatorcontrib><creatorcontrib>Golub, Andrija</creatorcontrib><creatorcontrib>Dorosulić, Zdravko</creatorcontrib><creatorcontrib>Sabol Pušić, Mateja</creatorcontrib><creatorcontrib>Boban, Marko</creatorcontrib><title>Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia</title><title>Journal of clinical ultrasound</title><addtitle>J Clin Ultrasound</addtitle><description>Purpose
The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2).
Materials and Methods
Seventy‐five consecutive adult patients hospitalized for treatment of CAP were recruited in this single‐center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists. Follow‐up assessment was performed within 2 to 4 weeks of ending antibiotic treatment at radiographic resolution of CAP. Fifteen patients were excluded during follow‐up due to confirmation of chronic obstructive pulmonary disease.
Results
Pneumonia was unilateral in 40 (66.7%) and bilateral in 20 (33.3%) patients. Radiographic extent of pneumonia involved 2 pulmonary segments in 31 patients (51.7%), 3 to 5 pulmonary segments in 25 (41.7%), and 6 pulmonary segments in 4 patients (6.6%). ΔPASP between hospital admission and follow‐up correlated with the number of pulmonary segments involved (Rho = 0.953; P < .001) and PaO2 (Rho = −0.667; P < .001). The maximum PASP was greater during pneumonia than after resolution (34.82 ± 3.96 vs. 22.67 ± 4.04, P < .001).
Conclusions
Changes in PASP strongly correlated with radiological severity of CAP and PaO2. During pneumonia, PASP appeared increased without significant change in left ventricular filling pressures. This suggests that disease‐related changes in lung tissue caused by pneumonia may easily and reproducibly be assessed using conventional noninvasive bedside diagnostics such as echocardiography and arterial blood gas analysis.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Antibiotics</subject><subject>arterial blood gas</subject><subject>Blood gas analysis</subject><subject>Blood pressure</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cohort Studies</subject><subject>Communities</subject><subject>Community-Acquired Infections - diagnostic imaging</subject><subject>Community-Acquired Infections - physiopathology</subject><subject>community‐acquired pneumonia</subject><subject>Correlation</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler</subject><subject>Female</subject><subject>Gas analysis</subject><subject>Heart</subject><subject>Humans</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obstructive lung disease</subject><subject>Oxygen - blood</subject><subject>Oxygenation</subject><subject>Partial Pressure</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Pneumonia</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - diagnostic imaging</subject><subject>Pneumonia - physiopathology</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary Artery - diagnostic imaging</subject><subject>Pulmonary Artery - physiopathology</subject><subject>pulmonary artery systolic pressure</subject><subject>respiratory dynamics</subject><subject>Segments</subject><subject>Systolic pressure</subject><subject>Ultrasonic imaging</subject><subject>Ventricle</subject><issn>0091-2751</issn><issn>1097-0096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1TAQhS0EopfCghdAltjAIq3txEm8RFeUH1ViQ9fRxJnc6yvHTu245e54hO55O54ElxQWSKzOLL5zZjSHkJecnXHGxPlBpzMhpCgfkQ1nqikYU_VjssnCC9FIfkKexXhgjNVSyqfkRLSqYpXgG_Jjuwe3w0iNo3Oyk3cQjhTCglniMS7eGk3ngDGmgFT7ENDCgvTWLHsaYDB-F2DeZyjiDQazZLcb6JzHeY8BLPXfjjt0sBjv7rfAkOwSV7_205Rc9vz8fgf6OpmA2eow5TsMPCdPRrARXzzoKbm6eP91-7G4_PLh0_bdZaFLWZZFPQ7Q1sBbNZYKZQlCaWywF6BkI1uoe9m22I9cY8_0KFk7ZmPf6Ap5BSOUp-TNmjsHf50wLt1kokZrwaFPseOqEg1rmVIZff0PevApuHxdppqGq1bUTaberpQOPsaAYzcHM-XHdpx19411ubHud2OZffWQmPoJh7_kn4oycL4Ct8bi8f9J3eft1Rr5C1zHpjo</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Sreter, Katherina Bernadette</creator><creator>Budimir, Ivan</creator><creator>Golub, Andrija</creator><creator>Dorosulić, Zdravko</creator><creator>Sabol Pušić, Mateja</creator><creator>Boban, Marko</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1671-5540</orcidid></search><sort><creationdate>201801</creationdate><title>Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia</title><author>Sreter, Katherina Bernadette ; Budimir, Ivan ; Golub, Andrija ; Dorosulić, Zdravko ; Sabol Pušić, Mateja ; Boban, Marko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-6fda86a189f39e53a29ce7eb2a95758a6b588ebf1ceb0cf508fc35b7c4e14afa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Antibiotics</topic><topic>arterial blood gas</topic><topic>Blood gas analysis</topic><topic>Blood pressure</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cohort Studies</topic><topic>Communities</topic><topic>Community-Acquired Infections - diagnostic imaging</topic><topic>Community-Acquired Infections - physiopathology</topic><topic>community‐acquired pneumonia</topic><topic>Correlation</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler</topic><topic>Female</topic><topic>Gas analysis</topic><topic>Heart</topic><topic>Humans</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obstructive lung disease</topic><topic>Oxygen - blood</topic><topic>Oxygenation</topic><topic>Partial Pressure</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Pneumonia</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - diagnostic imaging</topic><topic>Pneumonia - physiopathology</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary Artery - diagnostic imaging</topic><topic>Pulmonary Artery - physiopathology</topic><topic>pulmonary artery systolic pressure</topic><topic>respiratory dynamics</topic><topic>Segments</topic><topic>Systolic pressure</topic><topic>Ultrasonic imaging</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sreter, Katherina Bernadette</creatorcontrib><creatorcontrib>Budimir, Ivan</creatorcontrib><creatorcontrib>Golub, Andrija</creatorcontrib><creatorcontrib>Dorosulić, Zdravko</creatorcontrib><creatorcontrib>Sabol Pušić, Mateja</creatorcontrib><creatorcontrib>Boban, Marko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sreter, Katherina Bernadette</au><au>Budimir, Ivan</au><au>Golub, Andrija</au><au>Dorosulić, Zdravko</au><au>Sabol Pušić, Mateja</au><au>Boban, Marko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia</atitle><jtitle>Journal of clinical ultrasound</jtitle><addtitle>J Clin Ultrasound</addtitle><date>2018-01</date><risdate>2018</risdate><volume>46</volume><issue>1</issue><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0091-2751</issn><eissn>1097-0096</eissn><abstract>Purpose
The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community‐acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2).
Materials and Methods
Seventy‐five consecutive adult patients hospitalized for treatment of CAP were recruited in this single‐center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists. Follow‐up assessment was performed within 2 to 4 weeks of ending antibiotic treatment at radiographic resolution of CAP. Fifteen patients were excluded during follow‐up due to confirmation of chronic obstructive pulmonary disease.
Results
Pneumonia was unilateral in 40 (66.7%) and bilateral in 20 (33.3%) patients. Radiographic extent of pneumonia involved 2 pulmonary segments in 31 patients (51.7%), 3 to 5 pulmonary segments in 25 (41.7%), and 6 pulmonary segments in 4 patients (6.6%). ΔPASP between hospital admission and follow‐up correlated with the number of pulmonary segments involved (Rho = 0.953; P < .001) and PaO2 (Rho = −0.667; P < .001). The maximum PASP was greater during pneumonia than after resolution (34.82 ± 3.96 vs. 22.67 ± 4.04, P < .001).
Conclusions
Changes in PASP strongly correlated with radiological severity of CAP and PaO2. During pneumonia, PASP appeared increased without significant change in left ventricular filling pressures. This suggests that disease‐related changes in lung tissue caused by pneumonia may easily and reproducibly be assessed using conventional noninvasive bedside diagnostics such as echocardiography and arterial blood gas analysis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28940421</pmid><doi>10.1002/jcu.22523</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1671-5540</orcidid></addata></record> |
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| subjects | Adult Adults Aged Antibiotics arterial blood gas Blood gas analysis Blood pressure Chronic obstructive pulmonary disease Cohort Studies Communities Community-Acquired Infections - diagnostic imaging Community-Acquired Infections - physiopathology community‐acquired pneumonia Correlation Doppler effect Echocardiography Echocardiography, Doppler Female Gas analysis Heart Humans Lung diseases Male Middle Aged Obstructive lung disease Oxygen - blood Oxygenation Partial Pressure Patients Peripheral blood Pneumonia Pneumonia - blood Pneumonia - diagnostic imaging Pneumonia - physiopathology Prospective Studies Pulmonary arteries Pulmonary artery Pulmonary Artery - diagnostic imaging Pulmonary Artery - physiopathology pulmonary artery systolic pressure respiratory dynamics Segments Systolic pressure Ultrasonic imaging Ventricle |
| title | Changes in pulmonary artery systolic pressure correlate with radiographic severity and peripheral oxygenation in adults with community‐acquired pneumonia |
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