Evolutionary genotypes of influenza A (H7N9) viruses over five epidemic waves in China

Since the first human case of influenza A (H7N9) infection was identified in March 2013, five epidemics have emerged in China. Diverse H7N9 virus genotypes created through reassortments were already detected in the first epidemic wave, but how the H7N9 virus genetic diversities have evolved during t...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2017-11, Vol.55, p.269-276
Main Authors: Ding, Xiao, Luo, Jiejian, Quan, Lijun, Wu, Aiping, Jiang, Taijiao
Format: Article
Language:English
Subjects:
China - epidemiology
Evolution
Evolution, Molecular
Genetic Variation
Genotype
H7N9
Humans
Influenza A Virus, H7N9 Subtype - classification
Influenza A Virus, H7N9 Subtype - genetics
Influenza virus
Influenza, Human - epidemiology
Influenza, Human - virology
Mutation
Phylogeny
Reassortant Viruses - genetics
Reassortment
RNA Replicase - chemistry
RNA Replicase - genetics
Structure-Activity Relationship
Viral Proteins - chemistry
Viral Proteins - genetics
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Summary:Since the first human case of influenza A (H7N9) infection was identified in March 2013, five epidemics have emerged in China. Diverse H7N9 virus genotypes created through reassortments were already detected in the first epidemic wave, but how the H7N9 virus genetic diversities have evolved during the subsequent epidemics remained unclear. Here, to assess the ongoing genetic evolution of H7N9 viruses, we performed in-depth investigations of the dynamic H7N9 genotypes in these waves. We found that the H7N9 genotypes in the second and third epidemic waves are more diverse than those in the first wave, due to new reassortments that occurred during the second wave. However, the number of different H7N9 genotypes identified in the fourth and fifth waves decreased significantly. Furthermore, we found that different dominant genotypes existed in each of the five epidemic waves, and these wave-specific genotypes possess unique mutations that are enriched in the PB2 protein. •A new reassortment for the H7N9 viruses emerged in the second epidemic wave.•The diversity of H7N9 genotypes decreased significantly in recent the fourth and fifth waves.•Wave-specific H7N9 genotypes possess unique mutations that are enriched in the PB2 protein.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2017.09.027