Serum Surfactant Protein D as a Biomarker for Measuring Lung Involvement in Obese Patients With Type 2 Diabetes

• Published in: The journal of clinical endocrinology and metabolism 2017-11, Vol.102 (11), p.4109-4116
• Main Authors: López-Cano, Carolina, Lecube, Albert, García-Ramírez, Marta, Muñoz, Xavier, Sánchez, Enric, Seminario, Asunción, Hernández, Marta, Ciudin, Andreea, Gutiérrez, Liliana, Hernández, Cristina, Simó, Rafael
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Biomarkers - blood; Body mass; Body mass index; Case-Control Studies; Complications; Diabetes; Diabetes Complications - blood; Diabetes Complications - diagnosis; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Enzyme-linked immunosorbent assay; Female; Humans; Impairment; Lung - physiopathology; Lung diseases; Lung Diseases - blood; Lung Diseases - complications; Lung Diseases - diagnosis; Male; Middle Aged; Obesity; Obesity - blood; Obesity - complications; Protein D; Proteins; Pulmonary Surfactant-Associated Protein D - blood; Regression analysis; Respiratory Function Tests; Sensitivity and Specificity; Spirometry; Surfactant protein D; Surfactants
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2017-00913

ContextLung impairment is a new target for late diabetic complications. Biomarkers that could help identify patients requiring functional respiratory tests have not been reported.ObjectiveOur aim was to examine whether serum surfactant protein D (SP-D) and A (SP-A) could be useful biomarkers of lung damage in obese patients with type 2 diabetes (T2D) without known lung disease.Design and SettingA case-control study conducted in an ambulatory obesity unit.PatientsForty-nine obese patients with T2D and 98 subjects without diabetes matched by age, sex, body mass index, and waist circumference were included.InterventionsSerum SP-D and SP-A levels were measured using enzyme-linked immunosorbent assay. Forced spirometry and static pulmonary volume were assessed.ResultsPatients with T2D exhibited higher serum SP-D concentrations than control subjects (P = 0.006). No differences in serum SP-A concentrations were observed. There was an inverse association between forced expiratory volume in 1 second (FEV1) and serum SP-D (r = −0.265; P = 0.029), as well as a significant positive relationship between SP-D concentration and residual volume (r = 0.293; P = 0.043). From receiver operating characteristic analysis, the best SP-D cutoff to identify a FEV1