Relationship between the Contents of Cyclins, Cyclin-Dependent Kinases, and Their Inhibitors in Whole Blood Mononuclear Leukocytes during the Postclinical Stage of Community-Acquired Pneumonia under the Influence of 1-GHz Microwaves

The contents of cyclins A1, B1, E1, and D1, cyclin-dependent kinases 2 and 4 (CDK2 and CDK4), cyclin-dependent kinase 2C inhibitor (p18), and cyclin-dependent kinase 1C inhibitor (p57) in whole blood mononuclear cells of practically healthy donors and convalescents from community-acquired pneumonia...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-09, Vol.163 (5), p.623-626
Main Authors: Zilov, V. G., Khadartsev, A. A., Terekhov, I. V., Bondar’, S. S.
Format: Article
Language:English
Subjects:
Adult
B cells
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Cycle - radiation effects
Cell Cycle Proteins - metabolism
Cells, Cultured
Community-Acquired Infections - complications
Community-Acquired Infections - metabolism
Cyclin A1 - metabolism
Cyclin-Dependent Kinase 2 - metabolism
Cyclin-Dependent Kinases - metabolism
Cyclins - metabolism
Humans
Internal Medicine
Laboratory Medicine
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - radiation effects
Male
Microwaves
Microwaves - adverse effects
Pathology
Pneumonia - complications
Pneumonia - metabolism
Young Adult
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Summary:The contents of cyclins A1, B1, E1, and D1, cyclin-dependent kinases 2 and 4 (CDK2 and CDK4), cyclin-dependent kinase 2C inhibitor (p18), and cyclin-dependent kinase 1C inhibitor (p57) in whole blood mononuclear cells of practically healthy donors and convalescents from community-acquired pneumonia were measured after cell exposure to low-intensity electromagnetic radiation of 1 GHz. The level of cyclins A1, D1, and B1, p57, and p18 proteins, and CDK2 was reduced in convalescents, while the content of cyclin B1 was elevated in both groups. A strong correlation was found between the content of cyclin B1 and the levels of cyclin A1 and CDK2 in convalescents. Single exposure of whole blood cells to 1-GHz microwaves was accompanied by an increase in the content of the analyzed factors (particularly, cyclins A1 and E1). These data indicate that radiation induced activation of the synthetic phase of the cell cycle.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3864-1