Combination therapy for bloodstream infections with carbapenemase-producing Enterobacteriaceae – Authors' reply

[...]we did several multivariate analyses, including models with the individual variables, models with the scores, and models with both, after checking for collinearity. [...]we stated that differences in clinical performance could not be discounted according to the Breslow test. BGG declares no com...

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Bibliographic Details
Published in:The Lancet infectious diseases 2017-10, Vol.17 (10), p.1020-1021
Main Authors: Gutiérrez-Gutiérrez, Belén, Bonomo, Robert A, Carmeli, Yehuda, Paterson, David L, Pascual, Alvaro, Rodríguez-Baño, Jesús
Format: Article
Language:English
Subjects:
Advisors
Anti-Bacterial Agents
Antibiotics
Bacteremia
Bacterial Proteins
beta-Lactamases
Carbapenem-Resistant Enterobacteriaceae
Carbapenemase
Enterobacteriaceae
Enterobacteriaceae Infections
Humans
Infections
Infectious diseases
Microbial Sensitivity Tests
Mortality
Variables
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Summary:[...]we did several multivariate analyses, including models with the individual variables, models with the scores, and models with both, after checking for collinearity. [...]we stated that differences in clinical performance could not be discounted according to the Breslow test. BGG declares no competing interests. 1 B Gutiérrez-Gutiérrez, E Salamanca, M de Cueto, Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study, Lancet Infect Dis, Vol. 17, 2017, 726-734 2 SE Boyd, LSP Moore, TM Rawson, WW Hope, AH Holmes, Combination therapy for carbapenemase-producing Enterobacteriaceae: INCREMENT-al effect on resistance remains unclear, Lancet Infect Dis, Vol. 17, 2017, 899-900 3 M Paul, A Lador, S Grozinsky-Glasberg, L Leibovici, Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis, Cochrane Database Syst Rev, Vol. 1, 2014, CD003344.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(17)30522-4