Short Report: Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation

Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrel...

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Published in:British journal of haematology 2005-11, Vol.131 (4), p.483-486
Main Authors: Giebel, Sebastian, Locatelli, Franco, Wojnar, Jerzy, Velardi, Andrea, Mina, Tommaso, Giorgiani, Giovanna, Krawczyk-Kulis, Malgorzata, Markiewicz, Miroslaw, Wylezol, Iwona, Holowiecki, Jerzy
Format: Article
Language:English
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Summary:Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05797.x