Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises

Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained s...

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Bibliographic Details
Published in:Vox sanguinis 2017-11, Vol.112 (8), p.806-809
Main Authors: Hackstein, H., Möller, A., Gerlach, M., Sachs, U., Bein, G.
Format: Article
Language:English
Subjects:
blood component production
Blood Component Transfusion - standards
Blood flow
Blood Preservation - methods
blood processing
Cell Separation - instrumentation
Cell Separation - methods
Centrifugation
fresh frozen plasma
Gravitation
Hematocrit
Hemolysis
Humans
Leukocyte Count
Leukocytes
Priming
Prospective Studies
Quality Control
Relief Work
Separation
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Summary:Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV, FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.
ISSN:0042-9007
1423-0410
DOI:10.1111/vox.12595