Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises

Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained s...

Full description

Saved in:
Bibliographic Details
Published in:Vox sanguinis 2017-11, Vol.112 (8), p.806-809
Main Authors: Hackstein, H., Möller, A., Gerlach, M., Sachs, U., Bein, G.
Format: Article
Language:English
Subjects:
blood component production
Blood Component Transfusion - standards
Blood flow
Blood Preservation - methods
blood processing
Cell Separation - instrumentation
Cell Separation - methods
Centrifugation
fresh frozen plasma
Gravitation
Hematocrit
Hemolysis
Humans
Leukocyte Count
Leukocytes
Priming
Prospective Studies
Quality Control
Relief Work
Separation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3
cites cdi_FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3
container_end_page 809
container_issue 8
container_start_page 806
container_title Vox sanguinis
container_volume 112
creator Hackstein, H.
Möller, A.
Gerlach, M.
Sachs, U.
Bein, G.
description Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV, FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.
doi_str_mv 10.1111/vox.12595
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1943642409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1943642409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3</originalsourceid><addsrcrecordid>eNp10c9OFTEUBvDGSOCCLHwB08SNLAZO_8xMZ2mIigkJLIS4m3Q6p1LSmV7amYuTuOARfEafxMJFFyZ207T59ctJP0JeMzhmeZ1swvdjxsumfEFWTHJRgGTwkqwAJC8agHqP7Kd0CwCKq3KX7HHVlJyVbEV-XMaQ1mgmt0F6N2vvpoWaME4xeJqmuV9osFTTMWzQ029RbzL49fCzj_nBSO9vgkfa-RB6mnCto55cGGla0oQDTbObdJeBDZHezIMe8zk6PVITXcL0iuxY7RMePu8H5Orjhy-nZ8X5xafPp-_PCyNKURaCV2hNxaVShjMFdZ9ve4GNlYAGK1HaqhPY9VahqpEJrEFZJZlRtWQdigPybpu7juFuxjS1g0sGvdcjhjm1rJGiklxCk-nbf-htmOOYp8uqAgWyrkRWR1tl8u-liLZdRzfouLQM2sdK2lxJ-1RJtm-eE-duwP6v_NNBBidbcO88Lv9Paq8vvm4jfwNBZ5kQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1960804763</pqid></control><display><type>article</type><title>Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Hackstein, H. ; Möller, A. ; Gerlach, M. ; Sachs, U. ; Bein, G.</creator><creatorcontrib>Hackstein, H. ; Möller, A. ; Gerlach, M. ; Sachs, U. ; Bein, G.</creatorcontrib><description>Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV, FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.</description><identifier>ISSN: 0042-9007</identifier><identifier>EISSN: 1423-0410</identifier><identifier>DOI: 10.1111/vox.12595</identifier><identifier>PMID: 28952151</identifier><language>eng</language><publisher>England: S. Karger AG</publisher><subject>blood component production ; Blood Component Transfusion - standards ; Blood flow ; Blood Preservation - methods ; blood processing ; Cell Separation - instrumentation ; Cell Separation - methods ; Centrifugation ; fresh frozen plasma ; Gravitation ; Hematocrit ; Hemolysis ; Humans ; Leukocyte Count ; Leukocytes ; Priming ; Prospective Studies ; Quality Control ; Relief Work ; Separation</subject><ispartof>Vox sanguinis, 2017-11, Vol.112 (8), p.806-809</ispartof><rights>2017 International Society of Blood Transfusion</rights><rights>2017 International Society of Blood Transfusion.</rights><rights>Copyright © 2017 International Society of Blood Transfusion</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3</citedby><cites>FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3</cites><orcidid>0000-0001-9722-8180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28952151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hackstein, H.</creatorcontrib><creatorcontrib>Möller, A.</creatorcontrib><creatorcontrib>Gerlach, M.</creatorcontrib><creatorcontrib>Sachs, U.</creatorcontrib><creatorcontrib>Bein, G.</creatorcontrib><title>Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises</title><title>Vox sanguinis</title><addtitle>Vox Sang</addtitle><description>Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV, FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.</description><subject>blood component production</subject><subject>Blood Component Transfusion - standards</subject><subject>Blood flow</subject><subject>Blood Preservation - methods</subject><subject>blood processing</subject><subject>Cell Separation - instrumentation</subject><subject>Cell Separation - methods</subject><subject>Centrifugation</subject><subject>fresh frozen plasma</subject><subject>Gravitation</subject><subject>Hematocrit</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Leukocytes</subject><subject>Priming</subject><subject>Prospective Studies</subject><subject>Quality Control</subject><subject>Relief Work</subject><subject>Separation</subject><issn>0042-9007</issn><issn>1423-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp10c9OFTEUBvDGSOCCLHwB08SNLAZO_8xMZ2mIigkJLIS4m3Q6p1LSmV7amYuTuOARfEafxMJFFyZ207T59ctJP0JeMzhmeZ1swvdjxsumfEFWTHJRgGTwkqwAJC8agHqP7Kd0CwCKq3KX7HHVlJyVbEV-XMaQ1mgmt0F6N2vvpoWaME4xeJqmuV9osFTTMWzQ029RbzL49fCzj_nBSO9vgkfa-RB6mnCto55cGGla0oQDTbObdJeBDZHezIMe8zk6PVITXcL0iuxY7RMePu8H5Orjhy-nZ8X5xafPp-_PCyNKURaCV2hNxaVShjMFdZ9ve4GNlYAGK1HaqhPY9VahqpEJrEFZJZlRtWQdigPybpu7juFuxjS1g0sGvdcjhjm1rJGiklxCk-nbf-htmOOYp8uqAgWyrkRWR1tl8u-liLZdRzfouLQM2sdK2lxJ-1RJtm-eE-duwP6v_NNBBidbcO88Lv9Paq8vvm4jfwNBZ5kQ</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Hackstein, H.</creator><creator>Möller, A.</creator><creator>Gerlach, M.</creator><creator>Sachs, U.</creator><creator>Bein, G.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9722-8180</orcidid></search><sort><creationdate>201711</creationdate><title>Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises</title><author>Hackstein, H. ; Möller, A. ; Gerlach, M. ; Sachs, U. ; Bein, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>blood component production</topic><topic>Blood Component Transfusion - standards</topic><topic>Blood flow</topic><topic>Blood Preservation - methods</topic><topic>blood processing</topic><topic>Cell Separation - instrumentation</topic><topic>Cell Separation - methods</topic><topic>Centrifugation</topic><topic>fresh frozen plasma</topic><topic>Gravitation</topic><topic>Hematocrit</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Priming</topic><topic>Prospective Studies</topic><topic>Quality Control</topic><topic>Relief Work</topic><topic>Separation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hackstein, H.</creatorcontrib><creatorcontrib>Möller, A.</creatorcontrib><creatorcontrib>Gerlach, M.</creatorcontrib><creatorcontrib>Sachs, U.</creatorcontrib><creatorcontrib>Bein, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vox sanguinis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hackstein, H.</au><au>Möller, A.</au><au>Gerlach, M.</au><au>Sachs, U.</au><au>Bein, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises</atitle><jtitle>Vox sanguinis</jtitle><addtitle>Vox Sang</addtitle><date>2017-11</date><risdate>2017</risdate><volume>112</volume><issue>8</issue><spage>806</spage><epage>809</epage><pages>806-809</pages><issn>0042-9007</issn><eissn>1423-0410</eissn><abstract>Centrifugation‐based whole blood (WB) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation (n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV, FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.</abstract><cop>England</cop><pub>S. Karger AG</pub><pmid>28952151</pmid><doi>10.1111/vox.12595</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-9722-8180</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0042-9007
ispartof Vox sanguinis, 2017-11, Vol.112 (8), p.806-809
issn 0042-9007
1423-0410
language eng
recordid cdi_proquest_miscellaneous_1943642409
source Wiley-Blackwell Read & Publish Collection
subjects blood component production
Blood Component Transfusion - standards
Blood flow
Blood Preservation - methods
blood processing
Cell Separation - instrumentation
Cell Separation - methods
Centrifugation
fresh frozen plasma
Gravitation
Hematocrit
Hemolysis
Humans
Leukocyte Count
Leukocytes
Priming
Prospective Studies
Quality Control
Relief Work
Separation
title Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T14%3A21%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prospective%20quality%20control%20study%20of%20a%20novel%20gravity%E2%80%90driven%20whole%20blood%20separation%20system%20suitable%20for%20humanitarian%20crises&rft.jtitle=Vox%20sanguinis&rft.au=Hackstein,%20H.&rft.date=2017-11&rft.volume=112&rft.issue=8&rft.spage=806&rft.epage=809&rft.pages=806-809&rft.issn=0042-9007&rft.eissn=1423-0410&rft_id=info:doi/10.1111/vox.12595&rft_dat=%3Cproquest_cross%3E1943642409%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3535-326efc62488c21807d535d3e9f40ece635f6b3ebdf8e87e13e708f841c8741be3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1960804763&rft_id=info:pmid/28952151&rfr_iscdi=true