New Medical Textile Materials Koletex: Effective Multifunctional Depot Systems

Koletex - composite medical textile - represents a wide set of therapeutic bandages on a textile base. The medical efficacy of these bandages is determined by (i) the special structure of the base material, which comprises a bimodal (micro- and macro-) system of pores, (ii) a special composition bas...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2005-03, Vol.39 (3), p.154-163
Main Authors: Oltarzhevskaya, N. D., Krichevskii, G. E.
Format: Article
Language:English
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Summary:Koletex - composite medical textile - represents a wide set of therapeutic bandages on a textile base. The medical efficacy of these bandages is determined by (i) the special structure of the base material, which comprises a bimodal (micro- and macro-) system of pores, (ii) a special composition based on a natural biopolymer (sodium alginate, collagen, chitosan, etc.), and (iii) special textile technology (imprinting, dressing) of composite formation. As a result, the material forms a twofold depot from which active substances are supplied via the skin (interphase transdermal drug transfer model) to a wound or tumor. A methodological approach to the choice of textile base, biopolymers, immobilized drugs, and technological conditions for the production of koletex bandages of various types depending on their proposed usage is described.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-005-0107-y