Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-l/cisplatin in gastric cancer

High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-l/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2007-01, Vol.96 (2), p.277-283
Main Authors: Kamoshida, S, Suzuki, M, Shimomura, R, Sakurai, Y, Komori, Y, Uyama, I, Tsutsumi, Y
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-l/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from 41 gastric cancers were immunostained for TS and p53 protein after appropriate antigen retrieval. Fifty-one cases without neoadjuvant chemotherapy were also studied. In the pretreatment biopsies, high expression of TS was seen in 89% of the histologic responders, in 28% of the nonresponders and in 31% of the controls. High expression of p53 was observed in 56% of the nonresponders, but in 8% of the responders and in 29% of the controls (P
ISSN:0007-0920
DOI:10.1038/sj.bjc.6603546