Typhoid vaccine development with a human challenge model

While challenge models are sometimes controversial, they offer enormous potential to study the pathogenesis of disease and to accelerate vaccine development, particularly in human-restricted pathogens such as Salmonella enterica serovar Typhi. The Maryland typhoid human challenge model, which ran fr...

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Bibliographic Details
Published in:The Lancet (British edition) 2017-12, Vol.390 (10111), p.2419-2421
Main Authors: Feasey, Nicholas A, Levine, Myron M
Format: Article
Language:English
Subjects:
Biomedical Research
Humans
Immunization
Pathogenesis
Salmonella typhi - immunology
Typhoid
Typhoid Fever - immunology
Typhoid-Paratyphoid Vaccines - immunology
Vaccine development
Vaccines
Waterborne diseases
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Summary:While challenge models are sometimes controversial, they offer enormous potential to study the pathogenesis of disease and to accelerate vaccine development, particularly in human-restricted pathogens such as Salmonella enterica serovar Typhi. The Maryland typhoid human challenge model, which ran from 1952 to 1974, led to insights into typhoid fever and facilitated the development of live attenuated typhoid vaccine Ty21a.2,3 A 21st-century typhoid challenge model has been developed by the Oxford Vaccine Group.4
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(17)32407-8