Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation

Moxonidine is a centrally acting antihypertensive agent with a selectivity to I1-imidazoline receptors higher than that to α2-adrenergic receptors. The present study aimed to quantify a peripheral effect of moxonidine on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) regulation...

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Published in:Life sciences (1973) 2017-12, Vol.190, p.103-109
Main Authors: Kawada, Toru, Shimizu, Shuji, Yamamoto, Hiromi, Miyamoto, Tadayoshi, Shishido, Toshiaki, Sugimachi, Masaru
Format: Article
Language:English
Subjects:
Adrenergic receptors
Animals
Antihypertensive Agents - pharmacology
Antihypertensives
Arterial Pressure - drug effects
Baroreceptors
Baroreflex - drug effects
Blood pressure
Carotid sinus
Carotid Sinus - drug effects
Carotid Sinus - metabolism
Carotid sinus baroreflex
Clinical trials
Drug delivery systems
Drugs
Imidazoles - administration & dosage
Imidazoles - pharmacology
Imidazoline
Imidazoline agonist
Imidazoline receptors
Infusions, Intravenous
Injections, Intravenous
Intravenous administration
Male
Mercury
Moxonidine
Open-loop systems analysis
Rats
Rats, Wistar
Receptors
Receptors (physiology)
Reflexes
Rodents
Selectivity
Sinus
Sympathetic nerve activity
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - metabolism
Vasoconstriction - drug effects
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creator Kawada, Toru
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Yamamoto, Hiromi
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description Moxonidine is a centrally acting antihypertensive agent with a selectivity to I1-imidazoline receptors higher than that to α2-adrenergic receptors. The present study aimed to quantify a peripheral effect of moxonidine on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) regulation separately from its central effect. In eight anesthetized Wistar rats, changes in efferent sympathetic nerve activity (SNA) and AP in response to a carotid sinus pressure input were compared before and during an intravenous administration of moxonidine (100μgkg−1 bolus followed by a continuous infusion at 200μg·kg−1·h−1). Moxonidine significantly narrowed the range of the AP response (55.3±5.8 to 39.1±6.1mmHg, P
doi_str_mv 10.1016/j.lfs.2017.09.038
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Moxonidine increased AP at any given SNA, suggesting that the peripheral vasoconstrictive effect is stronger than generally recognized. The peripheral vasoconstrictive effect of moxonidine may partly offset the vasodilatory effect attained by centrally-mediated sympathoinhibition. 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Moxonidine increased AP at any given SNA, suggesting that the peripheral vasoconstrictive effect is stronger than generally recognized. The peripheral vasoconstrictive effect of moxonidine may partly offset the vasodilatory effect attained by centrally-mediated sympathoinhibition. [Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>28964815</pmid><doi>10.1016/j.lfs.2017.09.038</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4429-1802</orcidid></addata></record>
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ispartof Life sciences (1973), 2017-12, Vol.190, p.103-109
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subjects Adrenergic receptors
Animals
Antihypertensive Agents - pharmacology
Antihypertensives
Arterial Pressure - drug effects
Baroreceptors
Baroreflex - drug effects
Blood pressure
Carotid sinus
Carotid Sinus - drug effects
Carotid Sinus - metabolism
Carotid sinus baroreflex
Clinical trials
Drug delivery systems
Drugs
Imidazoles - administration & dosage
Imidazoles - pharmacology
Imidazoline
Imidazoline agonist
Imidazoline receptors
Infusions, Intravenous
Injections, Intravenous
Intravenous administration
Male
Mercury
Moxonidine
Open-loop systems analysis
Rats
Rats, Wistar
Receptors
Receptors (physiology)
Reflexes
Rodents
Selectivity
Sinus
Sympathetic nerve activity
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - metabolism
Vasoconstriction - drug effects
title Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation
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