Survey on the Original Plant Species of Crude Drugs Distributed as Cynanchi Wilfordii Radix and Its Related Crude Drugs in the Korean and Chinese Markets

Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Jap...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2017/10/01, Vol.40(10), pp.1693-1699
Main Authors: Sato-Masumoto, Naoko, Uchikura, Takashi, Sugiwaki, Hidemi, Yoshimura, Morio, Masada, Sayaka, Atsumi, Toshiyuki, Watanabe, Masato, Tanaka, Nobuyuki, Uchiyama, Nahoko, Amakura, Yoshiaki, Hakamatsuka, Takashi
Format: Article
Language:English
Subjects:
China
Chromatography, High Pressure Liquid
Cynanchum - chemistry
Cynanchum - genetics
Cynanchum auriculatum
Cynanchum wilfordii
DNA, Plant - analysis
Drugs
Food
Food production
genetic polymorphism
Health hazards
Health risks
high-performance thin-layer chromatography analysis
Natural & organic foods
Plant Preparations - chemistry
Polygonum multiflorum
Republic of Korea
Sequence Analysis, DNA
Species
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Summary:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitted to be distributed as a pharmaceutical regulated by the Japanese Pharmacopoeia 17th edition (JP17). Although CWR and CAR have not traditionally been used as medicines, CWR was recently introduced as a health food. The distribution of unfamiliar CWR-containing products could lead to the misuse of original species for PMR and CWR like in Korea. To prevent this situation, the original species of plant products distributed as PMR, CWR, and CAR in the Korean and Chinese markets were surveyed and identified by their genes and components. The results revealed that all two PMR in the Korean market were misapplied as CAR, and that CAR was incorrectly used in eight of thirteen products distributed as CWR in both markets. As PMR is strictly controlled by JP17, the risk of mistaking PMR for CWR and CAR would be low in Japan. In contrast, the less stringent regulation of health food products and the present situation of misidentification of CWR in the Korean and Chinese markets could lead to unexpected health hazards. To ensure the quality and safety of crude drugs, it is important to use the information about the genes and components of these crude drugs.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b17-00226