Early rescue Neopuff for infants with transient tachypnea of newborn: a randomized controlled trial

Objective: To examine the efficacy of early continuous positive airway pressure (CPAP), delivered using a T-piece-based infant resuscitator (Neopuff) via a face mask, in reducing the severity and duration of transient tachypnea of the newborn (TTN) as well as testing a hypothesis suggesting that rap...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2019-02, Vol.32 (4), p.597-603
Main Authors: Osman, Amani Mahmoud, El-Farrash, Rania Ali, Mohammed, Enas Hussein
Format: Article
Language:English
Subjects:
B-type natriuretic peptide
continuous positive airway pressure
Continuous Positive Airway Pressure - instrumentation
Continuous Positive Airway Pressure - methods
Double-Blind Method
Female
Humans
Infant, Newborn
Infant, Premature
Length of Stay - statistics & numerical data
Male
Masks - standards
Natriuretic Peptide, Brain - blood
Neopuff
Respiratory distress
Severity of Illness Index
Time Factors
transient tachypnea of newborn
Transient Tachypnea of the Newborn - blood
Transient Tachypnea of the Newborn - therapy
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Summary:Objective: To examine the efficacy of early continuous positive airway pressure (CPAP), delivered using a T-piece-based infant resuscitator (Neopuff) via a face mask, in reducing the severity and duration of transient tachypnea of the newborn (TTN) as well as testing a hypothesis suggesting that rapid clearance of fetal lung fluid to the circulation via CPAP would increase plasma B-type natriuretic peptide (BNP). Methods: A randomized controlled trial (NCT01859533) was conducted on 64 late preterm/term neonates, delivered by cesarean section and presented by respiratory distress shortly after birth. The Neopuff group included 34 neonates received 20 min of early CPAP and control group included 30 neonates received free flow O 2 . Plasma BNP was measured baseline and 2 h later. Results: The duration of tachypnea was shorter in Neopuff group with less need of neonatal intensive care unit admission and need of mechanical support (p  .05). Plasma BNP showed no significant difference between pre- and post-Neopuff levels (p > .05). A positive correlation was found between BNP and duration of tachypnea as well as the length of hospitalization (p 
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2017.1387531